Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.4355 | 0.5022 |
Plasmodium vivax | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative | 0.0066 | 0.183 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.8618 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.4355 | 0.5022 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0256 | 0.0303 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0256 | 0.0237 |
Plasmodium falciparum | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative | 0.0066 | 0.183 | 0.5 |
Echinococcus multilocularis | geminin | 0.0168 | 0.676 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.676 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1014 | 0.1122 |
Echinococcus granulosus | geminin | 0.0168 | 0.676 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1014 | 0.1122 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.4355 | 0.5022 |
Mycobacterium ulcerans | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | 0.0215 | 0.9051 | 0.5 |
Mycobacterium leprae | Probable 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) (MEP | 0.0215 | 0.9051 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.8618 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1014 | 0.1122 |
Mycobacterium tuberculosis | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (MEP cytidylyltransferase) (MCT) | 0.0149 | 0.5839 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1014 | 0.1122 |
Toxoplasma gondii | hypothetical protein | 0.0066 | 0.183 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0053 | 0.0078 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.676 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 1 | 0.5 |
Chlamydia trachomatis | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | 0.0215 | 0.9051 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0066 | 0.183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0256 | 0.0237 |
Wolbachia endosymbiont of Brugia malayi | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 0.0066 | 0.183 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.