Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0015 | 0.2727 | 0.2727 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Entamoeba histolytica | aldose reductase, putative | 0.0031 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | FTZ F1 alpha | 0.0015 | 0.2727 | 0.2727 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0031 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0031 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0031 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase | 0.0031 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0031 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0022 | 0.5922 | 0.5922 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Leishmania major | aldo-keto reductase-like protein | 0.0031 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Toxoplasma gondii | aldose reductase, putative | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0015 | 0.2727 | 0.2727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0031 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0022 | 0.5922 | 0.5922 |
Entamoeba histolytica | aldose reductase, putative | 0.0031 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0015 | 0.2727 | 0.2727 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0015 | 0.2727 | 0.2727 |
Schistosoma mansoni | thyroid hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Trypanosoma brucei | prostaglandin f synthase | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0015 | 0.2727 | 0.2727 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0015 | 0.2727 | 0.2727 |
Onchocerca volvulus | 0.0015 | 0.2727 | 0.2727 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0015 | 0.2727 | 0.2727 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0015 | 0.2727 | 0.2727 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0015 | 0.2727 | 0.2727 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0015 | 0.2727 | 0.2727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0031 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0031 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0015 | 0.2727 | 0.2727 |
Giardia lamblia | Aldose reductase | 0.0031 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0015 | 0.2727 | 0.2727 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0015 | 0.2727 | 0.2727 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase | 0.0031 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0031 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0015 | 0.2727 | 0.2727 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0015 | 0.2727 | 0.2727 |
Plasmodium vivax | aldehyde reductase, putative | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0015 | 0.2727 | 0.2727 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0015 | 0.2727 | 0.2727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0031 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0015 | 0.2727 | 0.2727 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0015 | 0.2727 | 0.2727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0031 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0015 | 0.2727 | 0.2727 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0009 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0022 | 0.5922 | 0.5922 |
Schistosoma mansoni | coup transcription factor | 0.0015 | 0.2727 | 0.2727 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0015 | 0.2727 | 0.2727 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0015 | 0.2727 | 0.2727 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0015 | 0.2727 | 0.2727 |
Schistosoma mansoni | nuclear hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Schistosoma mansoni | thyroid hormone receptor | 0.0015 | 0.2727 | 0.2727 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0015 | 0.2727 | 0.2727 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0015 | 0.2727 | 0.2727 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0031 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0015 | 0.2727 | 0.2727 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0015 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2727 | 0.2727 |
Entamoeba histolytica | aldose reductase, putative | 0.0031 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0015 | 0.2727 | 0.2727 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.43 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0.45 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0.46 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 17 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 94 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.73 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -3 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 17 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 94 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 102 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.51 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.30674 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.