Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PAN domain-containing protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.056 | 0.6608 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0827 | 0.9895 | 0.5 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.0356 | 0.4103 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.0356 | 0.4103 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 0.16 | Relative binding affinity(RBA) for 50% displacement of [3H]-estradiol from Estrogen receptor compared to 17-beta-estradiol | ChEMBL. | 2296015 |
RBA (binding) | = 0.2 | Relative binding affinity(RBA) for 50% displacement of [3H]-mibolerone from Androgen receptor compared to testorone | ChEMBL. | 2296015 |
RBA (binding) | = 0.01 | Relative binding affinity(RBA) as ratio of progesterone and compound required to displace [3H]-org 2058 binding to Progesterone receptor by 50% | ChEMBL. | 2296015 |
RBA (binding) | = 0.16 | Relative binding affinity(RBA) for 50% displacement of [3H]-estradiol from Estrogen receptor compared to 17-beta-estradiol | ChEMBL. | 2296015 |
RBA (binding) | = 0.2 | Relative binding affinity(RBA) for 50% displacement of [3H]-mibolerone from Androgen receptor compared to testorone | ChEMBL. | 2296015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.