Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide Y receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0094 | 0.1395 | 0.1924 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0171 | 0.3152 | 0.4561 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Brugia malayi | hypothetical protein | 0.0079 | 0.1055 | 0.1413 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.0873 | 0.114 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0079 | 0.1055 | 0.2915 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0092 | 0.1356 | 0.1865 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0071 | 0.0873 | 0.25 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0094 | 0.1395 | 0.4065 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Echinococcus granulosus | nAChR subunit | 0.0092 | 0.1356 | 0.409 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0171 | 0.3152 | 0.4561 |
Schistosoma mansoni | nAChR subunit | 0.0079 | 0.1055 | 0.2915 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0079 | 0.1055 | 0.1413 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0083 | 0.1149 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Giardia lamblia | Telomerase catalytic subunit | 0.0083 | 0.1149 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0079 | 0.1055 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | orexin receptor type 2 | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | g protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0092 | 0.1356 | 0.1865 |
Brugia malayi | Dopamine receptor protein 2 | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | neuropeptide receptor | 0.0094 | 0.1395 | 0.4218 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Brugia malayi | AKH receptor | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0171 | 0.3152 | 1 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0092 | 0.1356 | 0.1356 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0171 | 0.3152 | 0.4561 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0171 | 0.3152 | 1 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0079 | 0.1055 | 0.2915 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0094 | 0.1395 | 0.1395 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | somatostatin receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Echinococcus multilocularis | acetylcholinesterase | 0.0071 | 0.0873 | 0.25 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Entamoeba histolytica | hypothetical protein | 0.0092 | 0.1356 | 0.5 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0256 | 0.5102 | 1 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0083 | 0.1149 | 0.5 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Schistosoma mansoni | nAChR subunit | 0.0171 | 0.3152 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0057 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0092 | 0.1356 | 0.3934 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Schistosoma mansoni | biogenic amine receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | G-protein coupled receptor | 0.0094 | 0.1395 | 0.1924 |
Brugia malayi | Serotonin receptor | 0.0094 | 0.1395 | 0.1924 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0079 | 0.1055 | 0.2915 |
Brugia malayi | larval opioid receptor | 0.0094 | 0.1395 | 0.1924 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0171 | 0.3152 | 1 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | g protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0094 | 0.1395 | 0.4065 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0094 | 0.1395 | 0.4065 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0094 | 0.1395 | 0.4218 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1149 | 0.5 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Onchocerca volvulus | 0.0171 | 0.3152 | 0.4092 | |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0079 | 0.1055 | 0.2915 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0171 | 0.3152 | 0.3152 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0094 | 0.1395 | 0.4218 |
Brugia malayi | ORL1-like opioid receptor | 0.0094 | 0.1395 | 0.1924 |
Echinococcus granulosus | carboxylesterase 5A | 0.0071 | 0.0873 | 0.25 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0094 | 0.1395 | 0.4218 |
Brugia malayi | hypothetical protein | 0.0079 | 0.1055 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Brugia malayi | Cation transporter family protein | 0.0171 | 0.3152 | 0.4561 |
Echinococcus multilocularis | sex peptide receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0079 | 0.1055 | 0.3098 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | g-protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | nAChR subunit | 0.0079 | 0.1055 | 0.2915 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Echinococcus granulosus | neuropeptide receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0094 | 0.1395 | 0.1395 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0171 | 0.3152 | 0.4561 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0873 | 0.0873 |
Echinococcus granulosus | fmrfamide receptor | 0.0094 | 0.1395 | 0.4218 |
Onchocerca volvulus | Putative nachr subunit | 0.0171 | 0.3152 | 0.4092 |
Schistosoma mansoni | nAChR subunit | 0.0171 | 0.3152 | 1 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0094 | 0.1395 | 0.4218 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0083 | 0.1149 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | neuropeptide receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0092 | 0.1356 | 0.3934 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Echinococcus granulosus | allatostatin A receptor | 0.0094 | 0.1395 | 0.4218 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0094 | 0.1395 | 0.4218 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Echinococcus granulosus | serotonin receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0171 | 0.3152 | 1 |
Brugia malayi | Dopamine receptor protein 1 | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0171 | 0.3152 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0079 | 0.1055 | 0.1413 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0303 | 0.6182 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0071 | 0.0873 | 0.2301 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.4981 | 0.4981 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0079 | 0.1055 | 0.1055 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Schistosoma mansoni | myosin xvIII | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | sulfakinin receptor protein | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0171 | 0.3152 | 0.3152 |
Echinococcus granulosus | neuropeptide s receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | g protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0873 | 0.0873 |
Echinococcus multilocularis | serotonin receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | somatostatin receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0171 | 0.3152 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Schistosoma mansoni | opsin-like receptor | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0171 | 0.3152 | 0.4561 |
Brugia malayi | neuropeptide F receptor | 0.0094 | 0.1395 | 0.1924 |
Echinococcus granulosus | acetylcholinesterase | 0.0071 | 0.0873 | 0.25 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0094 | 0.1395 | 0.4218 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0171 | 0.3152 | 0.4561 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus granulosus | neuropeptide receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0171 | 0.3152 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0094 | 0.1395 | 0.0664 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0079 | 0.1055 | 0.1413 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | Cation transporter family protein | 0.0171 | 0.3152 | 0.4561 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | carboxylesterase | 0.0071 | 0.0873 | 0.0873 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0092 | 0.1356 | 0.3934 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0171 | 0.3152 | 1 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0094 | 0.1395 | 0.4065 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0171 | 0.3152 | 0.3152 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0171 | 0.3152 | 0.4561 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.1395 | 0.4065 |
Onchocerca volvulus | 0.0171 | 0.3152 | 0.4092 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0171 | 0.3152 | 0.4561 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | LGC-31 protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0071 | 0.0873 | 0.0873 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0171 | 0.3152 | 1 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | serotonin receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0171 | 0.3152 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0171 | 0.3152 | 0.4561 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | nAChR subunit | 0.0171 | 0.3152 | 1 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0079 | 0.1055 | 0.1055 |
Echinococcus multilocularis | acetylcholinesterase | 0.0071 | 0.0873 | 0.25 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0171 | 0.3152 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0094 | 0.1395 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0083 | 0.1149 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.1395 | 0.4065 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0094 | 0.1395 | 0.4065 |
Schistosoma mansoni | biogenic amine receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0171 | 0.3152 | 1 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | opsin-like receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Schistosoma mansoni | nAChR subunit | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus granulosus | hypothetical protein | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | g protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | biogenic amine receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.1395 | 0.4218 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0094 | 0.1395 | 0.1924 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0171 | 0.3152 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1149 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | RE15519p | 0.0094 | 0.1395 | 0.1924 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0094 | 0.1395 | 0.4218 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0079 | 0.1055 | 0.1413 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0171 | 0.3152 | 0.4561 |
Brugia malayi | Telomerase reverse transcriptase | 0.0221 | 0.4291 | 0.6268 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0092 | 0.1356 | 0.1865 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0079 | 0.1055 | 0.3098 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus granulosus | sex peptide receptor | 0.0094 | 0.1395 | 0.4218 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0057 | 0.5 |
Echinococcus multilocularis | nAChR subunit | 0.0171 | 0.3152 | 1 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0171 | 0.3152 | 0.4561 |
Brugia malayi | putative neuropeptide receptor | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Onchocerca volvulus | 0.0171 | 0.3152 | 0.4092 | |
Echinococcus granulosus | glycine receptor subunit beta | 0.0171 | 0.3152 | 1 |
Onchocerca volvulus | 0.0092 | 0.1356 | 0.0588 | |
Echinococcus multilocularis | allatostatin A receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0171 | 0.3152 | 0.3152 |
Onchocerca volvulus | 0.0092 | 0.1356 | 0.0588 | |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | follicle stimulating hormone receptor | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0094 | 0.1395 | 0.1924 |
Echinococcus multilocularis | fmrfamide receptor | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | nAChR subunit | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0171 | 0.3152 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0171 | 0.3152 | 1 |
Onchocerca volvulus | 0.0171 | 0.3152 | 0.4092 | |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0171 | 0.3152 | 0.4561 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0171 | 0.3152 | 0.3152 |
Brugia malayi | Dopamine receptor | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0171 | 0.3152 | 1 |
Onchocerca volvulus | 0.0171 | 0.3152 | 0.4092 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0171 | 0.3152 | 0.3152 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0171 | 0.3152 | 0.4561 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | nAChR subunit | 0.0092 | 0.1356 | 0.409 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | hypothetical protein | 0.0079 | 0.1055 | 0.1413 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0079 | 0.1055 | 0.1413 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0094 | 0.1395 | 0.1924 |
Brugia malayi | GnHR receptor homolog | 0.0094 | 0.1395 | 0.1924 |
Schistosoma mansoni | nAChR subunit | 0.0171 | 0.3152 | 1 |
Echinococcus multilocularis | g protein coupled receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0094 | 0.1395 | 0.1924 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0171 | 0.3152 | 1 |
Schistosoma mansoni | adenoreceptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | nAChR subunit | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1356 | 0.1356 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Serotonin receptor | 0.0094 | 0.1395 | 0.1924 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0079 | 0.1055 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0171 | 0.3152 | 1 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0092 | 0.1356 | 0.1865 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0094 | 0.1395 | 0.4218 |
Echinococcus multilocularis | fmrfamide receptor | 0.0094 | 0.1395 | 0.4218 |
Brugia malayi | Cation transporter family protein | 0.0171 | 0.3152 | 0.4561 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0094 | 0.1395 | 0.1924 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | hypothetical protein | 0.0094 | 0.1395 | 0.1924 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0079 | 0.1055 | 0.1055 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1055 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0094 | 0.1395 | 0.1395 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0079 | 0.1055 | 0.1413 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.1395 | 0.4065 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0094 | 0.1395 | 0.4065 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1395 | 0.4065 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0094 | 0.1395 | 0.4065 |
Onchocerca volvulus | 0.0094 | 0.1395 | 0.0664 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0171 | 0.3152 | 0.4561 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.033 | 0.6778 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0171 | 0.3152 | 0.4561 |
Brugia malayi | neuropeptide F receptor | 0.0094 | 0.1395 | 0.1924 |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.1395 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.6778 | 0.6778 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0094 | 0.1395 | 0.4218 |
Brugia malayi | hypothetical protein | 0.0079 | 0.1055 | 0.1413 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.1395 | 0.4218 |
Echinococcus granulosus | acetylcholinesterase | 0.0071 | 0.0873 | 0.25 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0171 | 0.3152 | 1 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0094 | 0.1395 | 0.4218 |
Schistosoma mansoni | histamine h1 receptor | 0.0094 | 0.1395 | 0.4065 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0094 | 0.1395 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3152 | 0.3152 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.0873 | 0.114 |
Onchocerca volvulus | 0.0171 | 0.3152 | 0.4092 | |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.1395 | 0.4065 |
Brugia malayi | hypothetical protein | 0.0079 | 0.1055 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0171 | 0.3152 | 0.4561 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0079 | 0.1055 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1395 | 0.1395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Blood sugar lowering (functional) | 0 % | Ability to lower blood sugar level at the dose of 100 mg/kg in fasted rats, by using glucose tolerance test(GTT); NA=Inactive | ChEMBL. | 3701788 |
ED50 (functional) | = 39 mg kg-1 | Anticonvulsant activity in mice, (induced by subcutaneous administration of Metrazol.) after 0.5 hr of administration, for Phase-II screening | ChEMBL. | 2846842 |
ED50 (functional) | = 39 mg kg-1 | Anticonvulsant activity of the compound, 0.5 h after administration of compound in mice subjected to subcutaneous metrazole challenge (85 mg/kg) | ChEMBL. | 2544727 |
ED50 (functional) | = 39 mg kg-1 | Anticonvulsant activity in mice, (induced by subcutaneous administration of Metrazol.) after 0.5 hr of administration, for Phase-II screening | ChEMBL. | 2846842 |
ED50 (functional) | = 39 mg kg-1 | Anticonvulsant activity of the compound, 0.5 h after administration of compound in mice subjected to subcutaneous metrazole challenge (85 mg/kg) | ChEMBL. | 2544727 |
ED50 (functional) | = 86 mg kg-1 | Anticonvulsant activity in mice (induced by maximal electroshock )after 0.5 hr of administration, for Phase-II screening | ChEMBL. | 2846842 |
ED50 (functional) | = 86 mg kg-1 | Anticonvulsant activity of the compound, 0.5 h after administration in maximal electroshock mice model | ChEMBL. | 2544727 |
ED50 (functional) | = 86 mg kg-1 | Anticonvulsant activity in mice (induced by maximal electroshock )after 0.5 hr of administration, for Phase-II screening | ChEMBL. | 2846842 |
ED50 (functional) | = 86 mg kg-1 | Anticonvulsant activity of the compound, 0.5 h after administration in maximal electroshock mice model | ChEMBL. | 2544727 |
IC50 (binding) | > 800 uM | In vitro inhibition of [3H]-BTX-B binding to sodium channels in rat brain synapto-neurosomes | ChEMBL. | 2846842 |
IC50 (binding) | > 800 uM | In vitro inhibition of [3H]-BTX-B binding to sodium channels in rat brain synapto-neurosomes | ChEMBL. | 2846842 |
Inhibition (binding) | = 44 % | Displacement of [3H]-BTX-B from rat cerebral cortex voltage-gated sodium channel, 0.5 hr after 500 uM | ChEMBL. | 2544727 |
Inhibition (binding) | = 44 % | Displacement of [3H]-BTX-B from rat cerebral cortex voltage-gated sodium channel, 0.5 hr after 500 uM | ChEMBL. | 2544727 |
MES (functional) | 0 | Anticonvulsant activity in mice, induced by maximal electroshock for Phase-I screening; Active at 300 mg/kg | ChEMBL. | 2846842 |
Rotorod (ADMET) | 0 | Rotorod toxicity test of the compound in Phase-I screening was determined; Active at 30 mg/kg | ChEMBL. | 2846842 |
scMet (functional) | 0 | Anticonvulsant activity in mice, induced by subcutaneous administration of Metrazol for Phase-I screening; Active at 30 mg/kg | ChEMBL. | 2846842 |
TD50 (ADMET) | = 164 mg kg-1 | Rotorod toxicity test for the compound in Phase-II screening was determined | ChEMBL. | 2846842 |
TD50 (ADMET) | = 164 mg kg-1 | Anticonvulsant activity of the compound,0.5 h after administration in mice subjected to rotorod toxicity test | ChEMBL. | 2544727 |
TD50 (ADMET) | = 164 mg kg-1 | Rotorod toxicity test for the compound in Phase-II screening was determined | ChEMBL. | 2846842 |
TD50 (ADMET) | = 164 mg kg-1 | Anticonvulsant activity of the compound,0.5 h after administration in mice subjected to rotorod toxicity test | ChEMBL. | 2544727 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.