Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0145 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0145 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0 | 0.5 |
Brugia malayi | calpain family protein 1 | 0.0076 | 0.3365 | 0.3365 |
Schistosoma mansoni | lipoxygenase | 0.0097 | 0.5397 | 0.5397 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8207 | 0.8207 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8207 | 0.8207 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.8207 | 0.8207 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0 | 0.5 |
Echinococcus granulosus | calpain A | 0.008 | 0.3736 | 0.3736 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0139 | 0.9399 | 0.9399 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8207 | 0.8207 |
Brugia malayi | hypothetical protein | 0.0119 | 0.7457 | 0.7457 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1203 | 0.1203 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0076 | 0.3365 | 0.3365 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.7457 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0145 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | calpain A | 0.008 | 0.3736 | 0.3736 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.008 | 0.3736 | 0.3736 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.7457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.7457 | 0.7457 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.8207 | 0.8207 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.8207 | 0.8207 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0145 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0139 | 0.9399 | 0.9399 |
Brugia malayi | RNA binding protein | 0.0127 | 0.8207 | 0.8207 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3365 | 0.3365 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0145 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.008 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.8207 | 0.8207 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0 | 0.5 |
Brugia malayi | calpain family protein 1 | 0.0076 | 0.3365 | 0.3365 |
Schistosoma mansoni | lipoxygenase | 0.0139 | 0.9399 | 0.9399 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.1203 | 0.1203 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.008 | 0.3736 | 0.3736 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0053 | 0.1203 | 0.1203 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.8207 | 0.8207 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1203 | 0.1203 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8207 | 0.8207 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.8207 | 0.8207 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.8207 | 0.8207 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.008 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3365 | 0.3365 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.7457 | 0.7457 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0145 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8207 | 0.8207 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0145 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0076 | 0.3365 | 0.3365 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.08 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.81 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.82 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 7 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 72 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.77 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 7 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 72 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.12 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.76075 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.