Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0759 | 0.0053 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.072 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.072 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.072 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.3376 | 0.3566 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2289 | 0.2107 | 0.2107 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.072 | 0 | 0.5 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0759 | 0.0053 | 0.0148 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0759 | 0.0053 | 0.0148 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.072 | 0 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.8166 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.3376 | 0.3566 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.8166 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.084 | 0.0161 | 0.0161 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.3376 | 0.3566 | 0.3566 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.084 | 0.0161 | 0.0308 |
Trypanosoma cruzi | prolyl endopeptidase | 0.084 | 0.0161 | 0.0451 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.084 | 0.0161 | 0.0161 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.8166 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0759 | 0.0053 | 0.0148 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.3009 | 0.3074 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.8166 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.072 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.084 | 0.0161 | 0.0161 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.3376 | 0.3566 | 0.3566 |
Trypanosoma cruzi | oligopeptidase b | 0.0759 | 0.0053 | 0.0148 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.084 | 0.0161 | 0.0161 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.0161 | 0.0161 |
Entamoeba histolytica | hypothetical protein, conserved | 0.072 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.2289 | 0.2107 | 0.2107 |
Toxoplasma gondii | prolyl endopeptidase | 0.084 | 0.0161 | 0.0523 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.3376 | 0.3566 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0759 | 0.0053 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.3376 | 0.3566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1086 | 0.0492 | 0.0492 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.072 | 0 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.084 | 0.0161 | 0.0161 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0759 | 0.0053 | 0.5 |
Trypanosoma brucei | oligopeptidase b | 0.0759 | 0.0053 | 0.0148 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.3376 | 0.3566 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.8166 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0759 | 0.0053 | 0.0148 |
Mycobacterium tuberculosis | Probable peptidase | 0.0759 | 0.0053 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.072 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.072 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.3376 | 0.3566 | 0.3566 |
Trypanosoma brucei | prolyl endopeptidase | 0.084 | 0.0161 | 0.0451 |
Plasmodium falciparum | peptidase, putative | 0.072 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.3376 | 0.3566 | 0.3566 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0759 | 0.0053 | 0.0148 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED2 (ADMET) | = 0.36 mg kg-1 | Oral dose necessary to produce an excretion of 2 mequiv of Na+/kg in the rat urine in the 4-h period after peroral administration | ChEMBL. | 6502591 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.