Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2417 | 0.2417 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.4706 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.1122 | 0.1091 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.4706 | 1 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.4706 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.1122 | 0.1091 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.3121 | 0.2822 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.4706 | 0.4649 |
Schistosoma mansoni | lamin | 0.0026 | 0.3121 | 0.2616 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.2417 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0683 | 0.0279 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0015 | 0.0683 | 0.0583 |
Echinococcus multilocularis | lamin | 0.0026 | 0.3121 | 0.3047 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.3121 | 0.3047 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1122 | 0.1122 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0015 | 0.0683 | 0.0583 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0416 | 0.0416 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0015 | 0.0683 | 0.0583 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.3121 | 0.2822 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.4706 | 1 |
Echinococcus multilocularis | phd:f box containing protein | 0.0015 | 0.0683 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0107 | 0.0107 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.2417 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0015 | 0.0683 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3014 | 0.3014 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0683 | 0.0683 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0683 | 0.0683 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.2417 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.2417 | 1 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.4706 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.2417 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0683 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1122 | 0.1122 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0015 | 0.0683 | 0.0583 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0015 | 0.0683 | 0.0583 |
Onchocerca volvulus | 0.0026 | 0.3121 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1122 | 0.1122 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.1122 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.2417 | 0.431 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.2417 | 0.431 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0015 | 0.0683 | 0.0583 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.2417 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.3121 | 0.2616 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.4706 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.3121 | 0.3047 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.2417 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.2417 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.3121 | 0.3047 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.2417 | 0.431 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0683 | 0.0279 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.1122 | 0.139 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0033 | 0.4706 | 0.4706 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.3121 | 0.3121 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.4706 | 0.4649 |
Onchocerca volvulus | 0.0026 | 0.3121 | 1 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.2417 | 0.2088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0683 | 0.0683 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.2417 | 0.2088 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0683 | 0.0279 |
Echinococcus multilocularis | musashi | 0.0026 | 0.3121 | 0.3047 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2417 | 0.2417 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.2417 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.2417 | 1 |
Echinococcus granulosus | phd:f box containing protein | 0.0015 | 0.0683 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1122 | 0.1122 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0057 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.2417 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2417 | 0.2417 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.2417 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.2417 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.3121 | 0.2616 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.4706 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.3121 | 0.3047 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0683 | 0.0683 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.4706 | 1 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.4706 | 1 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0015 | 0.0683 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1122 | 0.1122 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.3121 | 0.3121 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.2417 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.2417 | 0.2088 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.2417 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0683 | 0.0683 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0683 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3121 | 0.3121 |
Brugia malayi | Augmenter of liver regeneration | 0.0033 | 0.4706 | 0.4476 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.41 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0.51 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.43 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 95 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 1.47 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -9 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 3 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 95 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.96 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.10213 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.