Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.5259 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0375 | 0.0375 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.6352 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.3537 | 0.529 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.3537 | 0.529 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.3537 | 0.529 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.6352 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.6352 | 0.5 |
Echinococcus granulosus | lamin | 0.0026 | 0.3537 | 0.529 |
Onchocerca volvulus | 0.0026 | 0.3537 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.3537 | 0.529 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.3537 | 0.529 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.5545 | 0.865 |
Brugia malayi | Inositol-1 | 0.0036 | 0.6352 | 0.6352 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.6352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0375 | 0.0375 |
Onchocerca volvulus | 0.0026 | 0.3537 | 0.5 | |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.6352 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.6352 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.6352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.5545 | 0.5545 |
Echinococcus multilocularis | lamin | 0.0026 | 0.3537 | 0.529 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.6352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3397 | 0.3397 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0375 | 0.0375 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.6352 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.3537 | 0.3537 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.6352 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.6352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.3537 | 0.3537 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.5259 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.3537 | 0.3537 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.6352 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.3537 | 0.529 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.6352 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3537 | 0.3537 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.5545 | 0.5545 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.6352 | 0.6352 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.6352 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.3537 | 0.529 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0375 | 0.0375 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.6352 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -2.64 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -2.61 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -2.41 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 2 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 79 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 95 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 10.29 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -7 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 79 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 95 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.96 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.08971 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.