Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0253 | 0.7246 | 0.7211 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0253 | 0.7246 | 0.7211 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0253 | 0.7246 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0253 | 0.7246 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.2377 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0253 | 0.7246 | 0.7211 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0124 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0253 | 0.7246 | 0.7211 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0124 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.0556 | 0.5 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0556 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Echinococcus multilocularis | hypothetical protein | 0.0148 | 0.3806 | 0.3728 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0077 | 0.1463 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0337 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0124 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0124 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0124 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0077 | 0.1463 | 0.5943 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0124 | 0.5 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0253 | 0.7246 | 0.7211 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0556 | 0.0606 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0124 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0077 | 0.1463 | 0.5943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0077 | 0.1463 | 0.5943 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.3806 | 0.517 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0124 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0253 | 0.7246 | 0.7211 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0077 | 0.1463 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.01 | 0.2211 | 0.293 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0077 | 0.1463 | 0.5 |
Echinococcus granulosus | Ion_trans_N domain containing protein | 0.0148 | 0.3806 | 0.3728 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.1463 | 0.5943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.0832 | 0.3141 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.59 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.33 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.08 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 43 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 96 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 4.26 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -3 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 43 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 96 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.55 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.28436 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.