Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | doublecortin family protein | 0.0039 | 0.124 | 0.124 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0253 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.124 | 0.124 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.001 | 0.0061 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0039 | 0.124 | 1 |
Trypanosoma brucei | ABC transporter, putative | 0.001 | 0.0061 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.124 | 0.124 |
Schistosoma mansoni | loxhd1 | 0.0039 | 0.124 | 0.1363 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0253 | 1 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.124 | 0.1305 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0231 | 0.9098 | 1 |
Brugia malayi | Doublecortin family protein | 0.0039 | 0.124 | 0.124 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0039 | 0.124 | 0.1305 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0162 | 0.6259 | 0.6879 |
Schistosoma mansoni | polycystin 1-related | 0.0039 | 0.124 | 0.1363 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0039 | 0.124 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.001 | 0.0061 | 0.0067 |
Schistosoma mansoni | lipoxygenase | 0.0231 | 0.9098 | 1 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0231 | 0.9098 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0253 | 1 | 1 |
Onchocerca volvulus | 0.0253 | 1 | 1 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0253 | 1 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0253 | 1 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.001 | 0.0061 | 0.5 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.001 | 0.0061 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0039 | 0.124 | 0.1305 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0039 | 0.124 | 0.1305 |
Brugia malayi | hypothetical protein | 0.0039 | 0.124 | 0.124 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0253 | 1 | 0.5 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.001 | 0.0061 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0039 | 0.124 | 0.1363 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.124 | 0.1305 |
Schistosoma mansoni | rab6-interacting | 0.0039 | 0.124 | 0.1363 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | RUN | 0.0039 | 0.124 | 0.1305 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.001 | 0.0061 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0039 | 0.124 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.124 | 0.124 |
Echinococcus multilocularis | RUN | 0.0039 | 0.124 | 0.1305 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0253 | 1 | 1 |
Trypanosoma cruzi | ABC transporter, putative | 0.001 | 0.0061 | 0.5 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0253 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.124 | 0.1363 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.13 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0.57 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.34 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 15 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 61 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 84 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.68 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 15 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 61 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 84 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.28 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.52769 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.