Detailed information for compound 602104

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.415 | Formula: C20H22N4
  • H donors: 1 H acceptors: 0 LogP: 4.33 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)[nH]c(cc2=NN=Cc1ccc(cc1)N(C)C)C
  • InChi: 1S/C20H22N4/c1-14-5-10-18-19(11-14)22-15(2)12-20(18)23-21-13-16-6-8-17(9-7-16)24(3)4/h5-13H,1-4H3,(H,22,23)
  • InChiKey: OUUYCCNQRJBSLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0028 0.0566 0.2639
Schistosoma mansoni glucose transporter 0.0011 0.0064 0.0296
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.008 0.2144 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.0465 0.2166
Brugia malayi major facilitator superfamily protein 0.0011 0.0064 0.0266
Echinococcus granulosus General substrate transporter 0.0069 0.1804 0.8412
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0011 0.0064 0.5
Onchocerca volvulus 0.0011 0.0064 1
Schistosoma mansoni protein kinase 0.0025 0.0465 0.2166
Plasmodium vivax CDK-related protein kinase 6, putative 0.0341 1 1
Echinococcus granulosus solute carrier family 22 0.0011 0.0064 0.0296
Schistosoma mansoni protein kinase 0.0025 0.0465 0.2166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0945 0.4408
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0566 0.2371
Trichomonas vaginalis conserved hypothetical protein 0.008 0.2144 1
Brugia malayi hypothetical protein 0.0011 0.0064 0.0266
Schistosoma mansoni sugar transporter 0.0011 0.0064 0.0296
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Brugia malayi Sugar transporter family protein 0.008 0.2144 0.8983
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0945 0.396
Loa Loa (eye worm) major facilitator superfamily transporter 0.0011 0.0064 0.0266
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0025 0.0465 0.0404
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0024 0.045 0.2096
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0025 0.0465 0.0617
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0024 0.045 0.1883
Plasmodium vivax proline--tRNA ligase, putative 0.0028 0.057 0.051
Loa Loa (eye worm) major facilitator superfamily transporter 0.0011 0.0064 0.0266
Loa Loa (eye worm) hypothetical protein 0.0024 0.045 0.1883
Chlamydia trachomatis lysine--tRNA ligase 0.0018 0.0264 0.5
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0016 0.0197 0.0641
Echinococcus multilocularis synaptic vesicle 2 protein 0.0011 0.0064 0.0296
Schistosoma mansoni sugar transporter 0.0011 0.0064 0.0296
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.013 0.3636 0.5495
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0566 0.2371
Onchocerca volvulus 0.0011 0.0064 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0018 0.0264 0.395
Onchocerca volvulus 0.0011 0.0064 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0566 0.2639
Onchocerca volvulus 0.0011 0.0064 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0025 0.0474 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0025 0.0474 0.1973
Schistosoma mansoni hypothetical protein 0.0028 0.0566 0.2639
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0025 0.0465 0.2166
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0028 0.057 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0474 0.1973
Schistosoma mansoni glucose transport protein 0.008 0.2144 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0566 0.2371
Onchocerca volvulus 0.0011 0.0064 1
Onchocerca volvulus 0.0011 0.0064 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0011 0.0064 0.0296
Echinococcus multilocularis lysyl tRNA synthetase 0.0018 0.0264 0.1229
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0024 0.045 0.1883
Loa Loa (eye worm) sugar transporter 0.008 0.2144 0.8983
Entamoeba histolytica protein kinase, putative 0.0025 0.0465 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Trypanosoma brucei THT1 - hexose transporter, putative 0.0025 0.0474 0.8107
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0465 0.1927
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Plasmodium vivax calcium-dependent protein kinase, putative 0.0025 0.0465 0.0404
Onchocerca volvulus 0.0011 0.0064 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0025 0.0465 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0025 0.0465 0.2166
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0025 0.0465 0.1946
Onchocerca volvulus 0.0011 0.0064 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0313 0.1312
Trypanosoma cruzi hexose transporter, putative 0.0025 0.0474 0.8107
Onchocerca volvulus 0.0011 0.0064 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0025 0.0465 0.2166
Onchocerca volvulus 0.0011 0.0064 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0025 0.0465 0.0617
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Schistosoma mansoni glucose transport protein 0.008 0.2144 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0024 0.045 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0474 0.1973
Brugia malayi Sugar transporter family protein 0.0011 0.0064 0.0266
Giardia lamblia Prolyl-tRNA synthetase 0.0024 0.045 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0025 0.0465 0.0404
Plasmodium vivax hexose transporter 0.008 0.2144 0.2094
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0024 0.045 0.9253
Onchocerca volvulus 0.0011 0.0064 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0566 0.2639
Trypanosoma cruzi hexose transporter 0.0025 0.0474 0.8107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0566 0.2639
Schistosoma mansoni hypothetical protein 0.0028 0.0566 0.2639
Echinococcus granulosus lysyl tRNA synthetase 0.0018 0.0264 0.1229
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0064 0.0266
Brugia malayi major facilitator superfamily protein 0.0011 0.0064 0.0266
Echinococcus granulosus Sugar transporter ERD6 protein 0.0011 0.0064 0.0296
Leishmania major glucose transporter, lmgt2 0.0025 0.0474 0.8107
Schistosoma mansoni hypothetical protein 0.0028 0.0566 0.2639
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0064 0.0266
Onchocerca volvulus 0.0011 0.0064 1
Echinococcus multilocularis calcium dependent protein kinase 0.0023 0.0419 0.1952
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Schistosoma mansoni lysyl-tRNA synthetase 0.0018 0.0264 0.1229
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0015 0.0182 1
Entamoeba histolytica protein kinase, putative 0.0025 0.0465 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.008 0.2144 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0025 0.0465 0.0404
Plasmodium falciparum calcium-dependent protein kinase 2 0.0025 0.0465 0.0404
Trichomonas vaginalis glucose transporter, putative 0.0025 0.0474 0.1973
Echinococcus granulosus solute carrier family 22 0.0011 0.0064 0.0296
Trypanosoma cruzi hexose transporter, putative 0.0025 0.0474 0.8107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Trypanosoma brucei THT1 - hexose transporter, putative 0.0025 0.0474 0.8107
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0018 0.0264 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0018 0.0264 0.1229
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0011 0.0064 0.0296
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Echinococcus granulosus solute carrier family 22 0.0011 0.0064 0.0296
Plasmodium falciparum calcium-dependent protein kinase 4 0.0025 0.0465 0.0404
Onchocerca volvulus 0.0011 0.0064 1
Echinococcus granulosus calcium dependent protein kinase 0.0023 0.0419 0.1952
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0945 0.4408
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.001 0.0021 0.0089
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0025 0.0465 0.0404
Brugia malayi hypothetical protein 0.0011 0.0064 0.0266
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0024 0.045 0.1855
Onchocerca volvulus 0.0011 0.0064 1
Leishmania major lysyl-tRNA synthetase, putative 0.0018 0.0264 0.395
Schistosoma mansoni hypothetical protein 0.0028 0.0566 0.2639
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.008 0.2144 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0025 0.0465 0.7919
Plasmodium vivax lysine--tRNA ligase, putative 0.0018 0.0264 0.0201
Schistosoma mansoni hypothetical protein 0.008 0.2144 1
Echinococcus granulosus solute carrier family 22 0.0011 0.0064 0.0296
Toxoplasma gondii protein kinase, putative 0.0227 0.6564 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0089 0.2387 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0028 0.057 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0028 0.057 1
Schistosoma mansoni sugar transporter 0.0011 0.0064 0.0296
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0028 0.057 0.0779
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.013 0.3636 0.3595
Echinococcus multilocularis General substrate transporter 0.0069 0.1804 0.8412
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.0465 0.2166
Schistosoma mansoni sugar transporter 0.0011 0.0064 0.0296
Echinococcus granulosus synaptic vesicle 2 protein 0.0011 0.0064 0.0296
Schistosoma mansoni protein kinase 0.0025 0.0465 0.2166
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0089 0.2387 1
Echinococcus multilocularis solute carrier family 22 0.0011 0.0064 0.0296
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0945 0.396
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Loa Loa (eye worm) hypothetical protein 0.0089 0.2387 1
Plasmodium falciparum hexose transporter 0.008 0.2144 0.2094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0945 0.4408
Brugia malayi hypothetical protein 0.0011 0.0064 0.0266
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0134 0.1383
Brugia malayi lysyl-tRNA synthetase 0.0018 0.0264 0.1104
Schistosoma mansoni glucose transport protein 0.008 0.2144 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0018 0.0264 0.0961
Loa Loa (eye worm) hypothetical protein 0.0018 0.0264 0.1104
Leishmania major glucose transporter, lmgt1 0.0025 0.0474 0.8107
Brugia malayi Sugar transporter family protein 0.0011 0.0064 0.0266
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0018 0.0264 0.395
Loa Loa (eye worm) sugar transporter 0.0011 0.0064 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0945 0.4408
Plasmodium falciparum protein kinase 7 0.0227 0.6564 0.6542
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.0465 0.2166
Trypanosoma brucei glucose transporter 1E 0.0025 0.0474 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.008 0.2144 1
Trichomonas vaginalis sugar transporter, putative 0.0025 0.0474 0.1973
Giardia lamblia Lysyl-tRNA synthetase 0.0018 0.0264 0.5182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0566 0.2639
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0024 0.045 0.2096
Brugia malayi Major Facilitator Superfamily protein 0.0011 0.0064 0.0266
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.0465 0.2166
Toxoplasma gondii facilitative glucose transporter GT1 0.008 0.2144 0.3201
Echinococcus multilocularis solute carrier family 22 0.0011 0.0064 0.0296
Toxoplasma gondii lysine-tRNA ligase 0.0018 0.0264 0.0308
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Echinococcus multilocularis solute carrier family 22 0.0011 0.0064 0.0296
Onchocerca volvulus Putative transporter 0.0011 0.0064 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0025 0.0465 0.0404
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0024 0.045 0.2096
Trypanosoma brucei THT1 - hexose transporter, putative 0.0025 0.0474 0.8107
Loa Loa (eye worm) hypothetical protein 0.0028 0.0566 0.2371
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0945 0.4408
Loa Loa (eye worm) hypothetical protein 0.0025 0.0465 0.1946
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Plasmodium falciparum lysine--tRNA ligase 0.0018 0.0264 0.0201
Echinococcus multilocularis GPCR, family 2 0.0028 0.0566 0.2639
Leishmania major protein kinase, putative 0.0025 0.0465 0.7919
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.008 0.2144 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.013 0.3636 0.3595
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.008 0.2144 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0018 0.0264 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0089 0.2387 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0028 0.057 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.008 0.2144 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0025 0.0465 0.0617
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Trypanosoma brucei glucose transporter 2A 0.0025 0.0474 0.8107
Onchocerca volvulus 0.0011 0.0064 1
Leishmania major glucose transporter, lmgt3 0.0025 0.0474 0.8107
Trichomonas vaginalis glucose transporter, putative 0.0025 0.0474 0.1973
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Plasmodium falciparum proline--tRNA ligase 0.0028 0.057 0.051
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0024 0.045 0.2096
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0465 0.2166
Loa Loa (eye worm) hypothetical protein 0.0061 0.1544 0.6469
Brugia malayi Cam kinase protein 1 0.0025 0.0465 0.1946
Loa Loa (eye worm) hypothetical protein 0.0024 0.045 0.1883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0945 0.4408
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0945 0.4408
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0025 0.0465 0.1946
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0028 0.057 1
Trypanosoma cruzi hexose transporter, putative 0.0025 0.0474 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0025 0.0465 0.2166
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0015 0.0182 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0025 0.0465 0.1946
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266
Onchocerca volvulus 0.0011 0.0064 1
Trypanosoma brucei glucose transporter, putative 0.0025 0.0474 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.008 0.2144 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0018 0.0264 0.3046
Brugia malayi latrophilin 2 splice variant baaae 0.0061 0.1544 0.6469
Echinococcus multilocularis solute carrier family 22 0.0011 0.0064 0.0296
Trichomonas vaginalis sugar transporter, putative 0.0025 0.0474 0.1973
Schistosoma mansoni hypothetical protein 0.0061 0.1544 0.7201
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0266

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -5.38 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 1.24 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.71 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 8 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 46 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 4.44 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -9 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 8 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 46 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.06 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.88098 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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