Detailed information for compound 60252

Basic information

Technical information
  • TDR Targets ID: 60252
  • Name: 3-chloro-N-(8,8-dimethyl-6,7-dihydro-5H-1,6-n aphthyridin-3-yl)-4-methoxybenzamide
  • MW: 345.823 | Formula: C18H20ClN3O2
  • H donors: 2 H acceptors: 2 LogP: 2.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)C(=O)Nc1cnc2c(c1)CNCC2(C)C
  • InChi: 1S/C18H20ClN3O2/c1-18(2)10-20-8-12-6-13(9-21-16(12)18)22-17(23)11-4-5-15(24-3)14(19)7-11/h4-7,9,20H,8,10H2,1-3H3,(H,22,23)
  • InChiKey: VWUFKYZFMHBPSZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-N-(8,8-dimethyl-6,7-dihydro-5H-1,6-naphthyridin-3-yl)-4-methoxy-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aminopeptidase 0.0281 0 0.5
Mycobacterium ulcerans methionine aminopeptidase 0.0281 0 0.5
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0281 0 0.5
Chlamydia trachomatis methionine aminopeptidase 0.0281 0 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2267 1 1
Mycobacterium ulcerans dipeptidase PepE 0.0281 0 0.5
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.2267 1 1
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0281 0 0.5
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0281 0 0.5
Loa Loa (eye worm) initiation factor 2-associated protein 0.2267 1 1
Leishmania major methionine aminopeptidase 2, putative 0.2267 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2267 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.2267 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.2267 1 1
Mycobacterium tuberculosis Dipeptidase PepE 0.0281 0 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0281 0 0.5
Echinococcus granulosus methionyl aminopeptidase 2 0.2267 1 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0281 0 0.5
Toxoplasma gondii methionine aminopeptidase 2, putative 0.2267 1 1
Plasmodium vivax methionine aminopeptidase 2, putative 0.2267 1 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0281 0 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0281 0 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2267 1 1
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0281 0 0.5
Mycobacterium ulcerans dipeptidase 0.0281 0 0.5
Treponema pallidum methionine aminopeptidase (map) 0.0281 0 0.5
Entamoeba histolytica methionine aminopeptidase, putative 0.2267 1 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0281 0 0.5
Giardia lamblia Methionine aminopeptidase 0.2267 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.2267 1 1
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.2267 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2267 1 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0281 0 0.5
Treponema pallidum aminopeptidase P 0.0281 0 0.5
Echinococcus multilocularis methionyl aminopeptidase 2 0.2267 1 1
Trypanosoma brucei methionine aminopeptidase 2, putative 0.2267 1 1
Chlamydia trachomatis aminopeptidase P 0.0281 0 0.5
Plasmodium falciparum methionine aminopeptidase 2 0.2267 1 1

Activities

Activity type Activity value Assay description Source Reference
Increase (functional) = 260 % Anticonvulsant activity of the compound was determined by using rat MEST test at 2 mg/kg p.o. 2 hr post-dose ChEMBL. 12729628
Log Ki (functional) = 8.1 Binding affinity at [3H]-SB-204,269 binding site expressed as pKi ChEMBL. 12729628

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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