Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0057 | 0.1366 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0048 | 0.0861 | 0.1063 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0057 | 0.1366 | 0.0988 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.111 | 0.73 |
Onchocerca volvulus | 0.0057 | 0.1366 | 0.5 | |
Brugia malayi | Rhodanese-like domain containing protein | 0.0057 | 0.1366 | 1 |
Onchocerca volvulus | 0.0057 | 0.1366 | 0.5 | |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0057 | 0.1366 | 0.1688 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0175 | 0.8094 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0048 | 0.0861 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1366 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0175 | 0.8094 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.016 | 0.7233 | 0.8937 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 0.7674 | 0.9482 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0057 | 0.1366 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0167 | 0.7674 | 0.9482 |
Trichomonas vaginalis | cdc25b, putative | 0.0057 | 0.1366 | 0.5 |
Trichomonas vaginalis | cdc25c, putative | 0.0057 | 0.1366 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0048 | 0.0861 | 0.1063 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0048 | 0.0861 | 0.1063 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0057 | 0.1366 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0048 | 0.0861 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1366 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0041 | 0.0419 | 0.0518 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0057 | 0.1366 | 0.1688 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0057 | 0.1366 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0041 | 0.0419 | 0.0518 |
Trichomonas vaginalis | cdc25b, putative | 0.0057 | 0.1366 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0057 | 0.1366 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0057 | 0.1366 | 0.5 |
Onchocerca volvulus | 0.0057 | 0.1366 | 0.5 | |
Brugia malayi | Rhodanese-like domain containing protein | 0.0057 | 0.1366 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0057 | 0.1366 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0048 | 0.0861 | 0.1063 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0048 | 0.0861 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.111 | 0.73 |
Onchocerca volvulus | 0.0057 | 0.1366 | 0.5 | |
Echinococcus granulosus | glutamate receptor 2 | 0.0048 | 0.0861 | 0.1063 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0048 | 0.0861 | 0.1063 |
Echinococcus granulosus | glutamate receptor NMDA | 0.016 | 0.7233 | 0.8937 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0048 | 0.0861 | 0.1063 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0057 | 0.1366 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0041 | 0.0419 | 0.0518 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 4.49 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 6.22 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 8.2 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 31 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 87 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 95 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 8.45 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 5 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 31 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 87 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 95 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.08 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.83176 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.