TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 307.342 | Formula: C16H21NO5
H donors: 0 H acceptors: 2 LogP: 1.94 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: N#CC[C@@H]1C(=O)O[C@H]2[C@@]34[C@H]1CC[C@@H]([C@H]4CC[C@](O2)(OO3)C)C
InChi: 1S/C16H21NO5/c1-9-3-4-12-10(6-8-17)13(18)19-14-16(12)11(9)5-7-15(2,20-14)21-22-16/h9-12,14H,3-7H2,1-2H3/t9-,10+,11+,12+,14-,15-,16-/m1/s1
InChiKey: KLTNVMIGHJIZKH-OSRHWTBPSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus multilocularis	allatostatin A receptor	0.0151	0.0175	0.0175
Onchocerca volvulus		0.0151	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	0.0175	0.1381
Onchocerca volvulus		0.0151	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	neuropeptide receptor A26	0.0151	0.0175	0.0175
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	fmrfamide receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	orexin receptor type 2	0.0151	0.0175	0.0175
Echinococcus granulosus	dro:myosuppressin receptor	0.0151	0.0175	0.0175
Onchocerca volvulus		0.0151	0.0175	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0151	0.0175	0.1364
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	adenoreceptor	0.0151	0.0175	0.1381
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Onchocerca volvulus		0.0151	0.0175	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0151	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	neuropeptides capa receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Schistosoma mansoni	amine GPCR	0.0151	0.0175	0.1381
Brugia malayi	putative neuropeptide receptor	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	0.0175	0.1381
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	0.0175	0.0175
Loa Loa (eye worm)	melatonin receptor type 1A	0.0151	0.0175	0.1364
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0151	0.0175	0.0175
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0151	0.0175	0.1364
Schistosoma mansoni	hypothetical protein	0.0151	0.0175	0.1381
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Brugia malayi	brahma associated protein 60 kDa	0.0089	0.0085	0.0658
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	biogenic amine receptor	0.0151	0.0175	0.1381
Brugia malayi	Protein kinase domain containing protein	0.0904	0.1285	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0151	0.0175	0.1364
Brugia malayi	RE15519p	0.0151	0.0175	0.1364
Echinococcus granulosus	neuropeptide Y receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	g-protein coupled receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	g protein coupled receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	histamine h1 receptor	0.0151	0.0175	0.1381
Onchocerca volvulus		0.0151	0.0175	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0151	0.0175	0.1381
Plasmodium vivax	hypothetical protein, conserved	0.0089	0.0085	0.5
Onchocerca volvulus		0.0151	0.0175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0151	0.0175	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	0.0175	0.1381
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0151	0.0175	0.1364
Onchocerca volvulus		0.0089	0.0085	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	opsin-like receptor	0.0151	0.0175	0.1381
Echinococcus granulosus	g protein coupled receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0151	0.0175	0.1364
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0089	0.0085	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	0.0175	0.1364
Echinococcus multilocularis	g protein coupled receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	0.0175	0.0175
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0151	0.0175	0.0175
Loa Loa (eye worm)	TK/FAK protein kinase	0.0904	0.1285	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0089	0.0085	0.0085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Schistosoma mansoni	hypothetical protein	0.0151	0.0175	0.1381
Echinococcus multilocularis	fmrfamide receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	g protein coupled receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	neuropeptides capa receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	amine GPCR	0.0151	0.0175	0.1381
Echinococcus granulosus	SWI:SNF matrix associated	0.0089	0.0085	0.0085
Onchocerca volvulus		0.0151	0.0175	1
Schistosoma mansoni	opsin-like receptor	0.0151	0.0175	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	g protein coupled receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	hypothetical protein	0.0151	0.0175	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Onchocerca volvulus		0.0151	0.0175	1
Echinococcus multilocularis	sex peptide receptor	0.0151	0.0175	0.0175
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.1926	0.2789	0.2782
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	neuropeptide Y receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.6823	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0085	0.5
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.1926	0.2789	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus multilocularis	protein tyrosine kinase	0.0893	0.1269	0.1269
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	0.0175	0.1381
Mycobacterium ulcerans	thymidine phosphorylase	0.6823	1	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.0089	0.0085	0.0658
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0151	0.0175	0.1381
Onchocerca volvulus		0.0151	0.0175	1
Echinococcus granulosus	protein tyrosine kinase	0.0893	0.1269	0.1269
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	0.0175	0.1381
Trypanosoma cruzi	cytochrome P450, putative	0.0038	0.0009	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0151	0.0175	0.1381
Brugia malayi	follicle stimulating hormone receptor	0.0151	0.0175	0.1364
Brugia malayi	GnHR receptor homolog	0.0151	0.0175	0.1364
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	amine GPCR	0.0151	0.0175	0.1381
Schistosoma mansoni	hypothetical protein	0.0089	0.0085	0.0666
Brugia malayi	brahma associated protein 60 kDa	0.0089	0.0085	0.0658
Schistosoma mansoni	brg-1 associated factor	0.0089	0.0085	0.0666
Leishmania major	cytochrome p450-like protein	0.0038	0.0009	1
Echinococcus granulosus	neuropeptide s receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	serotonin receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	myosin xvIII	0.0151	0.0175	0.1381
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	0.0175	0.1364
Brugia malayi	Serotonin receptor	0.0151	0.0175	0.1364
Echinococcus multilocularis	g-protein coupled receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	neuropeptide receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0151	0.0175	0.1381
Echinococcus granulosus	serotonin receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0151	0.0175	0.1381
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	0.0175	0.0175
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	0.0175	0.1381
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	0.0175	0.1381
Echinococcus multilocularis	neuropeptide receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0175	0.1381
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0175	0.1381
Trypanosoma cruzi	cytochrome P450, putative	0.0038	0.0009	1
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0089	0.0085	1
Echinococcus multilocularis	somatostatin receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	0.0175	0.0175
Brugia malayi	Melatonin receptor type 1A	0.0151	0.0175	0.1364
Brugia malayi	G-protein coupled receptor	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	biogenic amine receptor	0.0151	0.0175	0.1381
Echinococcus multilocularis	serotonin receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	TYRA-2 protein	0.0151	0.0175	0.1364
Onchocerca volvulus		0.0151	0.0175	1
Onchocerca volvulus		0.0151	0.0175	1
Brugia malayi	Cytochrome P450 family protein	0.0038	0.0009	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	0.0175	0.1364
Schistosoma mansoni	amine GPCR	0.0151	0.0175	0.1381
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0151	0.0175	0.1364
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	ORL1-like opioid receptor	0.0151	0.0175	0.1364
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Loa Loa (eye worm)	cytochrome P450 family protein	0.0038	0.0009	0.0072
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	0.0175	0.1381
Loa Loa (eye worm)	cytochrome P450 family protein	0.0038	0.0009	0.0072
Echinococcus multilocularis	SWI:SNF matrix associated	0.0089	0.0085	0.0085
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Brugia malayi	neuropeptide F receptor	0.0151	0.0175	0.1364
Brugia malayi	AKH receptor	0.0151	0.0175	0.1364
Brugia malayi	neuropeptide F receptor	0.0151	0.0175	0.1364
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0151	0.0175	0.1381
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0151	0.0175	0.1381
Chlamydia trachomatis	SWIB complex protein	0.0089	0.0085	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0151	0.0175	0.1364
Onchocerca volvulus		0.0151	0.0175	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0151	0.0175	0.0175
Echinococcus granulosus	hypothetical protein	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Schistosoma mansoni	neuropeptide f receptor 76f	0.0151	0.0175	0.1381
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	Dopamine receptor protein 2	0.0151	0.0175	0.1364
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Onchocerca volvulus		0.0151	0.0175	1
Onchocerca volvulus		0.0151	0.0175	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0089	0.0085	0.0085
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	0.0175	0.0175
Onchocerca volvulus		0.0151	0.0175	1
Schistosoma mansoni	biogenic amine receptor	0.0151	0.0175	0.1381
Schistosoma mansoni	growth hormone secretagogue receptor	0.0151	0.0175	0.1381
Echinococcus granulosus	neuropeptide receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	sex peptide receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Brugia malayi	larval opioid receptor	0.0151	0.0175	0.1364
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Brugia malayi	G protein-coupled receptor	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	G-protein coupled receptor	0.0151	0.0175	0.1364
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0151	0.0175	0.0175
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0175	0.1381
Loa Loa (eye worm)	brahma associated protein	0.0089	0.0085	0.0658
Echinococcus granulosus	allatostatin A receptor	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	Serotonin receptor	0.0151	0.0175	0.1364
Echinococcus multilocularis	thymidine phosphorylase	0.6823	1	1
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0175	0.1381
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0151	0.0175	0.1364
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	0.0175	0.0175
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0089	0.0085	1
Echinococcus multilocularis	neuropeptide s receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	dro:myosuppressin receptor	0.0151	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	hypothetical protein	0.0089	0.0085	0.0666
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0089	0.0085	0.5
Schistosoma mansoni	amine GPCR	0.0151	0.0175	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	neuropeptide FF receptor 2	0.0151	0.0175	0.0175
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Brugia malayi	putative neuropeptide receptor NPR1	0.0151	0.0175	0.1364
Echinococcus granulosus	orexin receptor type 2	0.0151	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0151	0.0175	1
Echinococcus granulosus	neuropeptide receptor	0.0151	0.0175	0.0175
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0151	0.0175	0.0175
Brugia malayi	Dopamine receptor	0.0151	0.0175	0.1364
Echinococcus multilocularis	g protein coupled receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	0.0175	0.0175
Echinococcus multilocularis	SWI:SNF matrix associated	0.0089	0.0085	0.0085
Echinococcus granulosus	somatostatin receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	fmrfamide receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	0.0175	0.0175
Brugia malayi	Cytochrome P450 family protein	0.0038	0.0009	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	CYP4Cod1	0.0038	0.0009	0.0072
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0151	0.0175	0.0175
Brugia malayi	G protein-coupled receptor F59B2.13	0.0151	0.0175	0.1364
Onchocerca volvulus		0.0151	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0151	0.0175	0.1364
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	0.0175	0.1381
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0151	0.0175	0.0175
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	0.0175	0.0175
Schistosoma mansoni	opsin-like receptor	0.0151	0.0175	0.1381
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Trypanosoma brucei	cytochrome P450, putative	0.0038	0.0009	1
Brugia malayi	sulfakinin receptor protein	0.0151	0.0175	0.1364
Schistosoma mansoni	hypothetical protein	0.0151	0.0175	0.1381
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0175	0.1381
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	0.0175	0.0175
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0151	0.0175	0.0175
Echinococcus multilocularis	SWI:SNF matrix associated	0.0089	0.0085	0.0085
Echinococcus granulosus	7tm_1 domain containing protein	0.0151	0.0175	0.0175
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0089	0.0085	1
Chlamydia trachomatis	DNA topoisomerase I	0.0089	0.0085	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0151	0.0175	0.1381
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0151	0.0175	0.1381
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0089	0.0085	0.0658
Onchocerca volvulus		0.0151	0.0175	1
Brugia malayi	Dopamine receptor protein 1	0.0151	0.0175	0.1364
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Schistosoma mansoni	hypothetical protein	0.0089	0.0085	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364
Echinococcus granulosus	G protein coupled receptor 139	0.0151	0.0175	0.0175
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0151	0.0175	0.0175
Schistosoma mansoni	tyrosine kinase	0.0893	0.1269	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	0.0175	0.0175
Echinococcus multilocularis	G protein coupled receptor 139	0.0151	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0151	0.0175	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0175	0.1364

Activities

Activity type	Activity value	Assay description	Source	Reference
Relative activity (functional)	= 0.036	Compound was evaluated for the antimalarial activity against Plasmodium falciparum W-2 clone and the activity relative to artemisinin was reported	ChEMBL.	10915061
Relative activity (functional)	= 0.17	Compound was evaluated for the antimalarial activity against Plasmodium falciparum D-6 clone and the activity relative to artemisinin was reported	ChEMBL.	10915061

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 161455

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 61011