Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.0577 | 0.0475 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0065 | 0 | 0.5 |
Trichomonas vaginalis | rotamase, putative | 0.0066 | 0.0107 | 0.0107 |
Echinococcus granulosus | glycogen phosphorylase | 0.021 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0577 | 0.0475 |
Echinococcus granulosus | acetylcholinesterase | 0.0073 | 0.0577 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0577 | 0.0475 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0066 | 0.0107 | 0.0107 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.021 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0073 | 0.0577 | 0.0475 |
Schistosoma mansoni | glycogen phosphorylase | 0.021 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0073 | 0.0577 | 0.0475 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.021 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0091 | 0.1799 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.021 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0073 | 0.0577 | 0.0475 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0091 | 0.1799 | 0.5 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0065 | 0 | 0.5 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0091 | 0.1799 | 0.1799 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.0577 | 0.0475 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0065 | 0 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0065 | 0 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0065 | 0 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.021 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0091 | 0.1799 | 0.1799 |
Chlamydia trachomatis | glycogen phosphorylase | 0.021 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.021 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.021 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.021 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.021 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0073 | 0.0577 | 0.0475 |
Schistosoma mansoni | glycogen phosphorylase | 0.021 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.021 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0073 | 0.0577 | 0.0475 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.021 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0091 | 0.1799 | 0.1799 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.021 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0073 | 0.0577 | 0.0475 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.021 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0091 | 0.1799 | 0.171 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0073 | 0.0577 | 0.0475 |
Echinococcus multilocularis | acetylcholinesterase | 0.0073 | 0.0577 | 0.0475 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.00001 M | Ability to prevent constrictions induced by SRS-A (slow reacting substance of anaphylaxis) in guinea pig ileum | ChEMBL. | 6313920 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.