TDR Targets

Basic information

Technical information

TDR Targets ID: 622233
Name: 2-chloro-N-[4-(2-pyridin-3-ylpiperidin-1-yl)s ulfonylphenyl]benzamide
MW: 455.957 | Formula: C23H22ClN3O3S
H donors: 1 H acceptors: 4 LogP: 3.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1Cl)Nc1ccc(cc1)S(=O)(=O)N1CCCCC1c1cccnc1
InChi: 1S/C23H22ClN3O3S/c24-21-8-2-1-7-20(21)23(28)26-18-10-12-19(13-11-18)31(29,30)27-15-4-3-9-22(27)17-6-5-14-25-16-17/h1-2,5-8,10-14,16,22H,3-4,9,15H2,(H,26,28)
InChiKey: OXWPOXBLWAKTLY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-chloro-N-[4-[[2-(3-pyridyl)-1-piperidyl]sulfonyl]phenyl]benzamide
2-chloro-N-[4-[[2-(3-pyridyl)-1-piperidinyl]sulfonyl]phenyl]benzamide
Oprea1_447568
ChemDiv1_014742

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	endoplasmin	0.0015	0.0873	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0008	0.0271	0.2334
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0008	0.0271	0.0185
Echinococcus multilocularis	heat shock protein	0.0015	0.0873	0.0792
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0008	0.0271	0.3102
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0008	0.0271	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Loa Loa (eye worm)	heat shock protein 75	0.0006	0.0087	0.1001
Echinococcus granulosus	heat shock protein	0.0015	0.0873	0.0792
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0008	0.0271	0.0589
Toxoplasma gondii	heat shock protein 90, putative	0.0015	0.0873	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trypanosoma brucei	Heat shock protein 83, putative	0.0015	0.0873	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Schistosoma mansoni	endoplasmin	0.0015	0.0873	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0008	0.0271	0.3102
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0008	0.0271	0.3102
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0012	0.0602	0.5
Trypanosoma brucei	heat shock protein 90, putative	0.0015	0.0873	1
Plasmodium vivax	heat shock protein 86, putative	0.0015	0.0873	1
Trichomonas vaginalis	heat shock protein, putative	0.0009	0.0358	0.4106
Trichomonas vaginalis	endoplasmin, putative	0.0009	0.0358	0.4106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Echinococcus granulosus	heat shock protein 90	0.0012	0.0602	0.0519
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0114	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0012	0.0602	0.6895
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0008	0.0271	0.2334
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0008	0.0271	0.0589
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.32	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0012	0.0602	0.5
Trypanosoma cruzi	heat shock protein 85, putative	0.0015	0.0873	0.2524
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Giardia lamblia	Grp94/Hsp90	0.0012	0.0602	0.5499
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0008	0.0271	0.0589
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0012	0.0602	0.0519
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0008	0.0271	0.3102
Trichomonas vaginalis	heat shock protein, putative	0.0012	0.0602	0.6895
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Echinococcus multilocularis	heat shock protein 90	0.0015	0.0873	0.0792
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Echinococcus multilocularis	heat shock protein 90	0.0012	0.0602	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Loa Loa (eye worm)	heat shock protein 90	0.0015	0.0873	1
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0008	0.0271	0.3102
Brugia malayi	Endoplasmin precursor	0.0015	0.0873	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trypanosoma brucei	heat shock protein 84, putative	0.0006	0.0087	0.1001
Plasmodium falciparum	endoplasmin, putative	0.0009	0.0358	0.345
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0012	0.0602	0.1582
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0008	0.0271	0.2334
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0008	0.0271	0.0185
Trichomonas vaginalis	heat shock protein, putative	0.0015	0.0873	1
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0006	0.0087	0.5
Schistosoma mansoni	heat shock protein	0.0015	0.0873	1
Brugia malayi	heat shock protein 90	0.0015	0.0873	1
Toxoplasma gondii	Hsp90 domain-containing protein	0.0006	0.0087	0.1001
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Toxoplasma gondii	heat shock protein 75, putative	0.0006	0.0087	0.1001
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0008	0.0271	0.3102
Loa Loa (eye worm)	endoplasmin	0.0015	0.0873	1
Schistosoma mansoni	heat shock protein	0.0015	0.0873	1
Trypanosoma brucei	heat shock protein 90, putative	0.0015	0.0873	1
Echinococcus granulosus	heat shock protein 90	0.0015	0.0873	0.0792
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trichomonas vaginalis	heat shock protein, putative	0.0012	0.0602	0.6895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Echinococcus granulosus	endoplasmin	0.0012	0.0602	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trichomonas vaginalis	heat shock protein, putative	0.0006	0.0087	0.1001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0271	0.2334
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0008	0.0271	0.2334
Trypanosoma cruzi	heat shock protein 90, putative	0.0009	0.0328	0.0772
Entamoeba histolytica	heat shock protein 90, putative	0.0015	0.0873	1
Mycobacterium ulcerans	heat shock protein 90	0.0012	0.0602	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Loa Loa (eye worm)	phosphatidylinositol 3	0.0008	0.0271	0.3102
Leishmania major	hypothetical protein, conserved	0.0041	0.334	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0008	0.0271	0.0185
Echinococcus multilocularis	endoplasmin	0.0012	0.0602	0.0519
Trypanosoma cruzi	heat shock protein 90, putative	0.0012	0.0602	0.1653
Plasmodium falciparum	heat shock protein 90	0.0015	0.0873	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0008	0.0271	0.0589
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0015	0.0873	0.2524
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0012	0.0602	0.5499
Trypanosoma cruzi	target of rapamycin kinase 3	0.0008	0.0271	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0012	0.0602	0.5
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0008	0.0271	0.3102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trypanosoma cruzi	heat shock protein 90, putative	0.0015	0.0873	0.2524
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0008	0.0271	0.0564
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Plasmodium vivax	endoplasmin, putative	0.0015	0.0873	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Toxoplasma gondii	heat shock protein HSP90	0.0015	0.0873	1
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0015	0.0873	1
Leishmania major	heat shock protein 83-1	0.0015	0.0873	0.2415
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0008	0.0271	0.0564
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0008	0.0271	0.0564
Trypanosoma brucei	heat shock protein, putative	0.0015	0.0873	1
Entamoeba histolytica	heat shock protein 90, putative	0.0015	0.0873	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.0015	0.0873	0.2524
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0271	0.2334
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0008	0.0271	0.0564
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0271	0.3102
Trypanosoma cruzi	heat shock protein 85, putative	0.0012	0.0602	0.1653
Trypanosoma cruzi	heat shock protein 85, putative	0.0015	0.0873	0.2524
Treponema pallidum	heat shock protein 90	0.0012	0.0602	0.5
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0008	0.0271	0.0564

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 622233