Detailed information for compound 626645

Basic information

Technical information
  • TDR Targets ID: 626645
  • Name: N-(2-fluorophenyl)-2-[1-(4-fluorophenyl)-4-ox opyrazolo[5,4-d]pyrimidin-5-yl]acetamide
  • MW: 381.336 | Formula: C19H13F2N5O2
  • H donors: 1 H acceptors: 3 LogP: 2.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1cnc2c(c1=O)cnn2c1ccc(cc1)F)Nc1ccccc1F
  • InChi: 1S/C19H13F2N5O2/c20-12-5-7-13(8-6-12)26-18-14(9-23-26)19(28)25(11-22-18)10-17(27)24-16-4-2-1-3-15(16)21/h1-9,11H,10H2,(H,24,27)
  • InChiKey: WHLKZEMFULDRIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-fluorophenyl)-2-[1-(4-fluorophenyl)-4-oxo-pyrazolo[5,4-d]pyrimidin-5-yl]acetamide
  • N-(2-fluorophenyl)-2-[1-(4-fluorophenyl)-4-oxo-5-pyrazolo[5,4-d]pyrimidinyl]acetamide
  • N-(2-fluorophenyl)-2-[1-(4-fluorophenyl)-4-keto-pyrazolo[5,4-d]pyrimidin-5-yl]acetamide
  • N-(2-fluorophenyl)-2-[1-(4-fluorophenyl)-4-oxo-pyrazolo[5,4-d]pyrimidin-5-yl]ethanamide
  • ZINC04165984

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.2892
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0117 0.2445
Leishmania major importin beta-1 subunit, putative 0.0046 0.0174 0.5427
Brugia malayi Importin beta-1 subunit 0.0057 0.0318 0.0295
Brugia malayi RNA, U transporter 1 0.0162 0.1722 0.1702
Schistosoma mansoni importin beta-1 0.0057 0.0318 0.0384
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0277 0.0253
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0024
Echinococcus granulosus importin subunit beta 1 0.0057 0.0318 0.0295
Loa Loa (eye worm) hypothetical protein 0.0054 0.0285 0.0234
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0277 1
Echinococcus granulosus zinc finger protein 0.0222 0.2534 0.2515
Loa Loa (eye worm) hypothetical protein 0.0057 0.0316 0.0265
Brugia malayi Thioredoxin reductase 0.0054 0.0277 0.0253
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.1199 0.8674
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.079 0.0768
Echinococcus multilocularis snurportin 1 0.0607 0.7684 0.7679
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0174 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.1199 0.8674
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0117 0.0093
Loa Loa (eye worm) glutathione reductase 0.0054 0.0277 0.0226
Entamoeba histolytica Ran family GTPase 0.0042 0.0117 0.6195
Schistosoma mansoni inositol monophosphatase 0.0037 0.0052 0.0036
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0277 0.0253
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0174 1
Echinococcus multilocularis muscleblind protein 0.078 1 1
Schistosoma mansoni ran 0.0042 0.0117 0.0121
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0607 0.7684 0.7672
Mycobacterium tuberculosis Probable reductase 0.0123 0.1199 0.8674
Loa Loa (eye worm) hypothetical protein 0.078 1 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0243 0.2814 0.2797
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0277 0.2002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.1383 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.079 0.0742
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0052 0.1853
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.1199 0.8674
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0318 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.079 0.0768
Onchocerca volvulus 0.0054 0.0285 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.1383 1
Echinococcus granulosus tumor protein p63 0.0372 0.4532 0.4518
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0052 0.0028
Loa Loa (eye worm) hypothetical protein 0.078 1 1
Echinococcus multilocularis muscleblind protein 1 0.078 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0052 0.0028
Echinococcus granulosus snurportin 1 0.0607 0.7684 0.7679
Echinococcus granulosus muscleblind protein 0.078 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.1383 1
Schistosoma mansoni zinc finger protein 0.0243 0.2814 0.3642
Trypanosoma brucei trypanothione reductase 0.0054 0.0277 0.8454
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0076 0.0052
Echinococcus multilocularis tumor protein p63 0.0372 0.4532 0.4518
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.0065
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.1199 0.8674
Loa Loa (eye worm) hypothetical protein 0.0057 0.0318 0.0267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0316 0.0292
Plasmodium vivax importin-beta 2, putative 0.0057 0.0318 1
Echinococcus multilocularis zinc finger protein 0.0222 0.2534 0.2515
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.5
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.2445
Plasmodium falciparum importin beta, putative 0.0057 0.0318 1
Plasmodium falciparum glutathione reductase 0.0054 0.0277 0.7953
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0277 0.0226
Schistosoma mansoni hypothetical protein 0.0039 0.0076 0.0067
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0318 0.0295
Leishmania major trypanothione reductase 0.0054 0.0277 1
Brugia malayi glutathione reductase 0.0054 0.0277 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.079 0.1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.079 0.0768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.079 0.0768
Trichomonas vaginalis ran, putative 0.0042 0.0117 0.5329
Loa Loa (eye worm) MBOAT family protein 0.0243 0.2814 0.2777
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.079 0.0768
Toxoplasma gondii thioredoxin reductase 0.0054 0.0277 0.8454
Schistosoma mansoni hypothetical protein 0.0607 0.7684 1
Plasmodium vivax glutathione reductase, putative 0.0054 0.0277 0.7953
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.079 0.1
Brugia malayi Inositol-1 0.0037 0.0052 0.0028
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0117 0.0093
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.0093
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0243 0.2814 0.2797
Leishmania major GTP-binding protein, putative 0.0042 0.0117 0.2892
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.1383 1
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0318 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.1199 0.8674
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0285 0.034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.1199 0.8674
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0318 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0316 0.0292
Brugia malayi MBOAT family protein 0.0243 0.2814 0.2797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.079 0.1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.2892
Schistosoma mansoni ran 0.0042 0.0117 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0174 1
Plasmodium falciparum thioredoxin reductase 0.0054 0.0277 0.7953
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0277 0.7953
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0052 0.5
Entamoeba histolytica hypothetical protein 0.0046 0.0174 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0052 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0316 0.0265
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0174 0.5427
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0052 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.