Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0087 | 0.3443 | 0.3443 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.845 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.845 | 1 |
Brugia malayi | hypothetical protein | 0.0087 | 0.3443 | 0.4075 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0319 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.3443 | 0.4075 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0319 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.3443 | 0.4075 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0319 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0319 | 0.0377 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.845 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.845 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.845 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.