Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | 0.0767 | 0.6268 | 0.7535 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0767 | 0.6268 | 0.7535 |
Toxoplasma gondii | PAN domain-containing protein | 0.0922 | 0.8199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 0.8319 | 0.8319 |
Toxoplasma gondii | PAN domain-containing protein | 0.0922 | 0.8199 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0932 | 0.8319 | 0.8319 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1067 | 1 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0932 | 0.8319 | 0.8319 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0932 | 0.8319 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 0.8319 | 0.8319 |
Loa Loa (eye worm) | hypothetical protein | 0.1067 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0932 | 0.8319 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0932 | 0.8319 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0932 | 0.8319 | 0.8319 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1067 | 1 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0932 | 0.8319 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0932 | 0.8319 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1067 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.3511 | 0.3511 |
Onchocerca volvulus | 0.0932 | 0.8319 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 0.8319 | 0.8319 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0932 | 0.8319 | 0.8319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.4 uM | Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3. | ChEMBL. | 9873411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.