Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 0.8319 | 0.8319 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 0.8319 | 0.8319 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1067 | 1 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0932 | 0.8319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1067 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0932 | 0.8319 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0932 | 0.8319 | 0.8319 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1067 | 1 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.0922 | 0.8199 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0932 | 0.8319 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0932 | 0.8319 | 1 |
Onchocerca volvulus | 0.0932 | 0.8319 | 1 | |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0932 | 0.8319 | 0.8319 |
Toxoplasma gondii | PAN domain-containing protein | 0.0922 | 0.8199 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0767 | 0.6268 | 0.7535 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0932 | 0.8319 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0932 | 0.8319 | 0.8319 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0767 | 0.6268 | 0.7535 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1067 | 1 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0932 | 0.8319 | 0.8319 |
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 0.8319 | 0.8319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.4 uM | Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3. | ChEMBL. | 9873411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.