Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Immunoglobulin | 0.014 | 0.2948 | 1 |
Echinococcus multilocularis | nephrin | 0.014 | 0.2948 | 1 |
Onchocerca volvulus | Galectin homolog | 0.0119 | 0 | 0.5 |
Echinococcus granulosus | nephrin | 0.014 | 0.2948 | 1 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.2948 | 1 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.2948 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.014 | 0.2948 | 1 |
Echinococcus granulosus | irregular chiasm roughest protein | 0.014 | 0.2948 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0178 | 0.8484 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.8484 | 0.8484 |
Echinococcus multilocularis | conserved hypothetical protein | 0.014 | 0.2948 | 1 |
Echinococcus granulosus | nephrin | 0.014 | 0.2948 | 1 |
Echinococcus multilocularis | irregular chiasm roughest protein immunoglobulin set domain containing protein | 0.014 | 0.2948 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0178 | 0.8484 | 0.8484 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0178 | 0.8484 | 1 |
Onchocerca volvulus | Galectin homolog | 0.0119 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.9 uM | Inhibitory activity of the compound against hepatitis C virus protease enzyme(HCV) by using ELISA replicon assay | ChEMBL. | 12729635 |
k obs / 1 (functional) | = 154 M-1 s-1 | Inhibitory activity of the compound against hepatitis C virus protease enzyme(HCV) NS3/4A | ChEMBL. | 12729635 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.