Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | mucolipin 3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0137 | 0.5412 | 0.6126 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1865 | 0.1731 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0861 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0498 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0137 | 0.5412 | 0.6126 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0137 | 0.5412 | 0.6126 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0137 | 0.5412 | 0.6238 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0498 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.8676 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0137 | 0.5412 | 0.6126 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0498 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8538 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8538 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1865 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1444 | 0.1665 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0468 | 0.0539 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.8676 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0861 | 0.0488 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0861 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1865 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0861 | 0.0547 |
Schistosoma mansoni | mucolipin | 0.0079 | 0.2728 | 0.2801 |
Schistosoma mansoni | mucolipin | 0.0072 | 0.2424 | 0.2424 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0468 | 0.0062 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0498 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0236 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0861 | 0.0488 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1865 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1865 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0137 | 0.5412 | 0.6126 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.07 | 0.0288 |
Brugia malayi | Coelomocyte uptake defective protein 5 | 0.0079 | 0.2728 | 0.3144 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0861 | 0.0993 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.07 | 0.0807 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8538 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0861 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1444 | 0.119 |
Echinococcus granulosus | mucolipin 3 | 0.0079 | 0.2728 | 0.2846 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0498 | 0.0037 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0861 | 0.0488 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1865 | 0.1731 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0137 | 0.5412 | 0.6151 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1865 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0498 | 0.5 |
Loa Loa (eye worm) | mucolipin 1 | 0.0079 | 0.2728 | 0.2754 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0861 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.07 | 0.0284 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1444 | 0.1665 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0498 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1444 | 0.119 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0137 | 0.5412 | 0.6023 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1865 | 0.1731 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0137 | 0.5412 | 0.6151 |
Brugia malayi | hypothetical protein | 0.003 | 0.0498 | 0.0574 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1865 | 1 |
Echinococcus multilocularis | mucolipin 3 | 0.0079 | 0.2728 | 0.2801 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0498 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.8538 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1865 | 0.1783 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.38 um | PUBCHEM_BIOASSAY: Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] | ChEMBL. | No reference |
EC50 (functional) | > 29.9 um | PUBCHEM_BIOASSAY: Fluorescence counterscreen assay for TRPML3 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] | ChEMBL. | No reference |
Potency (functional) | 0.13 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.5323 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.