Detailed information for compound 649014

Basic information

Technical information
  • TDR Targets ID: 649014
  • Name: 3-(1H-benzimidazol-2-yl)-6-methylchromen-2-on e
  • MW: 276.289 | Formula: C17H12N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.33 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)cc(c(=O)o2)c1nc2c([nH]1)cccc2
  • InChi: 1S/C17H12N2O2/c1-10-6-7-15-11(8-10)9-12(17(20)21-15)16-18-13-4-2-3-5-14(13)19-16/h2-9H,1H3,(H,18,19)
  • InChiKey: AHDRAUGWDUXXFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1H-benzimidazol-2-yl)-6-methyl-chromen-2-one
  • 3-(1H-benzimidazol-2-yl)-6-methyl-2-chromenone
  • 3-(1H-benzimidazol-2-yl)-6-methyl-coumarin
  • Oprea1_611728
  • ZINC00111274
  • EU-0075776
  • AN-989/40662533

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0382 0.3829 1
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Plasmodium falciparum protein kinase 5 0.0097 0.0874 0.7743
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0071 0.0071
Toxoplasma gondii hypothetical protein 0.0029 0.0172 0.1253
Echinococcus multilocularis cyclin B 0.0231 0.226 0.226
Brugia malayi hypothetical protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclin t1 0.0029 0.0172 0.0172
Loa Loa (eye worm) CYL-1 protein 0.0029 0.0172 0.0466
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0192
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0029 0.0172 0.097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.5
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0874 0.367
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.017 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0071 0.0185
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0874 0.367
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0401 0.1048
Echinococcus multilocularis muscleblind protein 0.018 0.1739 0.1739
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0029 0.0172 0.1253
Trichomonas vaginalis cyclins, putative 0.014 0.1323 0.5514
Brugia malayi hypothetical protein 0.0019 0.0067 0.0183
Brugia malayi hypothetical protein 0.0029 0.0174 0.0471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Trypanosoma brucei cyclin 3 0.0029 0.0172 0.046
Schistosoma mansoni cyclin k 0.0029 0.0172 0.0449
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0071 0.0193
Brugia malayi CHE-14 protein 0.0051 0.0401 0.1088
Trypanosoma cruzi cyclin 6, putative 0.0231 0.226 1
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0874 0.367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0418 0.1093
Echinococcus multilocularis G1:S specific cyclin D1 0.0029 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.017 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0323 0.0844
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0071 0.0071
Leishmania major hypothetical protein, conserved 0.0029 0.0174 0.0469
Plasmodium vivax protein kinase Crk2 0.0097 0.0874 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclin y 0.0029 0.0172 0.0172
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Brugia malayi cyclin fold protein 1 variant b 0.0029 0.0172 0.0466
Schistosoma mansoni patched 1 0.0051 0.0401 0.1048
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Loa Loa (eye worm) hypothetical protein 0.0111 0.1025 0.278
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0174 0.099
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1103 0.2882
Echinococcus granulosus cyclin dependent kinase 5 0.0097 0.0874 0.2284
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Echinococcus granulosus cyclin G2 0.0029 0.0172 0.0449
Echinococcus multilocularis protein dispatched 1 0.0058 0.0476 0.0476
Echinococcus granulosus G1:S specific cyclin D1 0.0029 0.0172 0.0449
Echinococcus multilocularis muscleblind protein 1 0.018 0.1739 0.1739
Entamoeba histolytica cyclin family protein 0.0119 0.1108 0.4491
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0874 0.367
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0008 0.0022
Giardia lamblia G2/mitotic-specific cyclin B 0.0231 0.226 1
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0323 0.0323
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0029 0.0172 0.0449
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0029 0.0172 0.0172
Echinococcus granulosus geminin 0.0382 0.3829 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0401 0.11
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0071 0.0192
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0369 0.3688 0.3688
Brugia malayi N-terminal motif family protein 0.02 0.1938 0.5255
Brugia malayi Cyclin, N-terminal domain containing protein 0.0231 0.226 0.6127
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1631 0.1631
Echinococcus granulosus cyclin t1 0.0029 0.0172 0.0449
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0874 0.3364
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0071
Trypanosoma brucei cdc2-related kinase 3 0.0097 0.0874 0.367
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0172 0.046
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0874 0.0874
Schistosoma mansoni cyclin B 0.0231 0.226 0.5903
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0071
Trypanosoma cruzi cyclin, putative 0.0231 0.226 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0451
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0496 0.1346
Onchocerca volvulus Cyclin L homolog 0.0029 0.0172 0.076
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0174 0.1279
Loa Loa (eye worm) hypothetical protein 0.0051 0.0401 0.1088
Trypanosoma cruzi mitotic cyclin, putative 0.0029 0.0172 0.046
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Onchocerca volvulus 0.0029 0.017 0.0752
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0097 0.0874 0.367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0874 0.2284
Toxoplasma gondii cyclin dependent kinase binding protein 0.0029 0.0172 0.1253
Brugia malayi hypothetical protein 0.0043 0.0323 0.0876
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.017 1
Echinococcus granulosus cyclin A3 4 0.0029 0.0172 0.0449
Loa Loa (eye worm) hypothetical protein 0.02 0.1938 0.5255
Echinococcus multilocularis GPCR, family 2 0.0019 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0029 0.0172 0.0449
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Echinococcus granulosus cyclin dependent kinase 1 0.0097 0.0874 0.2284
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1631 0.426
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0461
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Echinococcus granulosus cyclin b3 0.0119 0.1108 0.2895
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0097 0.0874 0.2371
Schistosoma mansoni hypothetical protein 0.0043 0.0323 0.0844
Loa Loa (eye worm) hypothetical protein 0.0062 0.052 0.141
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0071 0.0192
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Plasmodium falciparum cyclin 1 0.0029 0.0172 0.097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0418 0.0418
Schistosoma mansoni hypothetical protein 0.0041 0.0299 0.0782
Entamoeba histolytica cell division protein kinase 2, putative 0.0097 0.0874 0.337
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0071 0.0185
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0071 0.0186
Schistosoma mansoni cyclin d 0.0029 0.0172 0.0449
Trichomonas vaginalis cyclin A, putative 0.0231 0.226 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0496 0.1346
Trypanosoma cruzi CYC2-like cyclin, putative 0.0231 0.226 1
Brugia malayi Cyclin C 0.0029 0.0172 0.0466
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0095 0.2422
Echinococcus granulosus Cyclin L1 0.0029 0.0172 0.0449
Echinococcus granulosus cyclin dependent kinase 0.0097 0.0874 0.2284
Echinococcus granulosus cyclin y 0.0029 0.0172 0.0449
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0231 0.226 1
Echinococcus multilocularis cyclin b3 0.0119 0.1108 0.1108
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0186
Leishmania major cyclin 9, putative 0.0029 0.0172 0.046
Plasmodium vivax cyclin 4, putative 0.0029 0.0172 0.1253
Echinococcus granulosus cyclin B3 1 0.0119 0.1108 0.2895
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0071 0.0193
Loa Loa (eye worm) hypothetical protein 0.0096 0.0864 0.2342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0471
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Schistosoma mansoni hypothetical protein 0.0029 0.0172 0.0449
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0029 0.0172 0.0449
Loa Loa (eye worm) hypothetical protein 0.0041 0.0299 0.0812
Echinococcus granulosus cyclins 0.0029 0.0172 0.0449
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0451
Echinococcus granulosus GPCR family 2 0.0019 0.0071 0.0185
Loa Loa (eye worm) cyclin domain-containing protein 0.0369 0.3688 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0418 0.1093
Entamoeba histolytica cell division protein kinase 2, putative 0.0097 0.0874 0.337
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0174 0.0469
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0299 0.0812
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0071 0.0071
Plasmodium falciparum cyclin 0.0119 0.1108 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0174 0.099
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Schistosoma mansoni Cyclin fold protein 0.0029 0.0172 0.0449
Echinococcus multilocularis cyclin G2 0.0029 0.0172 0.0172
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Echinococcus granulosus cyclin k 0.0029 0.0172 0.0449
Mycobacterium ulcerans hypothetical protein 0.0029 0.017 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0461
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0097 0.0874 1
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0174 0.1279
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0401 0.0401
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Entamoeba histolytica cyclin, putative 0.0231 0.226 1
Schistosoma mansoni cyclins 0.0119 0.1108 0.2895
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0418 0.1134
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Schistosoma mansoni cyclin l 0.0029 0.0172 0.0449
Schistosoma mansoni cyclin B3 0.0369 0.3688 0.9634
Entamoeba histolytica cyclin C, putative 0.0029 0.0172 0.0009
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Trypanosoma cruzi cyclin, putative 0.0231 0.226 1
Echinococcus multilocularis cyclin G2 0.0029 0.0172 0.0172
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0874 0.3364
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1103 0.2991
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0369 0.3688 0.9634
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0095 0.0231
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0097 0.0874 0.2284
Trichomonas vaginalis cyclin B, putative 0.0119 0.1108 0.4486
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0008 0.0008
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0029 0.0172 0.1253
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0172 0.1253
Echinococcus multilocularis protein patched 0.0051 0.0401 0.0401
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Brugia malayi isocitrate dehydrogenase 0.0019 0.0071 0.0193
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Onchocerca volvulus Cyclin L homolog 0.0029 0.0172 0.076
Toxoplasma gondii cyclin 4, putative 0.0029 0.0172 0.1253
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0174 0.0469
Trichomonas vaginalis cyclins, putative 0.0119 0.1108 0.4486
Entamoeba histolytica cyclin, domain containing protein 0.0029 0.0172 0.0009
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.017 1
Entamoeba histolytica cyclin, putative 0.0119 0.1108 0.4491
Echinococcus multilocularis cyclin B3 1 0.0119 0.1108 0.1108
Echinococcus granulosus cyclin G2 0.0029 0.0172 0.0449
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0029 0.0172 0.046
Echinococcus multilocularis Cyclin L1 0.0029 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0022
Trypanosoma brucei cdc2-related kinase 1 0.0097 0.0874 0.367
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0071 0.0071
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0097 0.0874 0.367
Trypanosoma cruzi cyclin 9, putative 0.0029 0.0172 0.046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0418 0.1093
Trichomonas vaginalis cyclin D, putative 0.0119 0.1108 0.4486
Schistosoma mansoni cyclin G 0.0029 0.0172 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0461
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1103 0.1103
Entamoeba histolytica hypothetical protein 0.0029 0.0172 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0231 0.226 0.6127
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0874 0.2371
Echinococcus granulosus cyclin B 0.0231 0.226 0.5903
Trichomonas vaginalis cyclin B3, putative 0.0119 0.1108 0.4486
Trypanosoma brucei mitotic cyclin 0.0029 0.0172 0.046
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0095 0.5
Trypanosoma brucei mitotic cyclin 6 0.0231 0.226 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.1938 0.8576
Brugia malayi Cyclin, N-terminal domain containing protein 0.0369 0.3688 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0466
Echinococcus granulosus expressed conserved protein 0.0112 0.1029 0.2687
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Schistosoma mansoni cyclin G2 0.0029 0.0172 0.0449
Echinococcus granulosus cyclin y 0.0029 0.0172 0.0449
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Echinococcus multilocularis cyclin dependent kinase 5 0.0097 0.0874 0.0874
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1122 0.2931
Onchocerca volvulus Protein CNPPD1 homolog 0.0029 0.0172 0.076
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0874 0.3364
Brugia malayi cell division control protein 2 homolog 0.0097 0.0874 0.2371
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0095 0.0298
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0323 0.0844
Loa Loa (eye worm) hypothetical protein 0.0231 0.226 0.6127
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.0733
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0418 0.1093
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0451
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0401 0.1088
Plasmodium vivax cyclin homologue, putative 0.0029 0.0172 0.1253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0418 0.0418
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Entamoeba histolytica cyclin, domain containing protein 0.0029 0.0172 0.0009
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0029 0.0172 0.0466
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.017 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0461
Leishmania major mitotic cyclin, putative 0.0029 0.0172 0.046
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclin 0.0029 0.0172 0.0172
Echinococcus multilocularis geminin 0.0382 0.3829 0.3829
Echinococcus multilocularis expressed conserved protein 0.0112 0.1029 0.1029
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.1108 0.4486
Schistosoma mansoni hypothetical protein 0.0382 0.3829 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.1199
Loa Loa (eye worm) hypothetical protein 0.0119 0.1103 0.2991
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0029 0.0172 0.0449
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.0185
Trichomonas vaginalis cyclins, putative 0.0231 0.226 1
Onchocerca volvulus 0.0029 0.0172 0.076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0418 0.1093
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.0999
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0401 0.1048
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0029 0.0172 0.0172
Trichomonas vaginalis cyclin B, putative 0.0231 0.226 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0029 0.0172 0.097
Echinococcus granulosus cyclins 0.0119 0.1108 0.2895
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0874 0.3364
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Echinococcus granulosus muscleblind protein 0.018 0.1739 0.4543
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0874 0.3364
Trichomonas vaginalis cyclin D, putative 0.0119 0.1108 0.4486
Loa Loa (eye worm) hypothetical protein 0.018 0.1739 0.4715
Brugia malayi Muscleblind-like protein 0.018 0.1739 0.4715
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0461
Brugia malayi hypothetical protein 0.0029 0.0172 0.0466
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1103 0.4466
Echinococcus multilocularis cyclin y 0.0029 0.0172 0.0172
Echinococcus multilocularis cyclin dependent kinase 0.0097 0.0874 0.0874
Leishmania major mitotic cyclin, putative 0.0029 0.0172 0.046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0466
Loa Loa (eye worm) cyclin C 0.0029 0.0172 0.0466
Onchocerca volvulus 0.0231 0.226 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0071 0.0192
Trypanosoma cruzi mitotic cyclin, putative 0.0029 0.0172 0.046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0071 0.0071
Echinococcus granulosus cyclin 0.0029 0.0172 0.0449
Giardia lamblia Hypothetical protein 0.0119 0.1108 0.4486
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0874 0.0874
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Echinococcus multilocularis cyclins 0.0119 0.1108 0.1108
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0029 0.0172 0.1253
Loa Loa (eye worm) hypothetical protein 0.006 0.0496 0.1346
Toxoplasma gondii hypothetical protein 0.0091 0.0811 0.9206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Echinococcus multilocularis cyclin A3 4 0.0029 0.0172 0.0172
Entamoeba histolytica cyclin family protein 0.0119 0.1108 0.4491
Loa Loa (eye worm) hypothetical protein 0.0231 0.226 0.6127
Leishmania major cyclin 0.0231 0.226 1
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0874 0.2284
Giardia lamblia Cyclin A 0.0119 0.1108 0.4486
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.017 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.0172 0.0466
Loa Loa (eye worm) hypothetical protein 0.018 0.1739 0.4715
Brugia malayi Protein kinase domain containing protein 0.0097 0.0874 0.2371
Echinococcus multilocularis cyclin k 0.0029 0.0172 0.0172
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0496 0.1346
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0418 0.1134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0258
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0174 0.0469
Trypanosoma brucei cyclin 9 0.0029 0.0172 0.046
Schistosoma mansoni g1/s-specific cyclin C 0.0029 0.0172 0.0449
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0874 0.2371
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.0172 0.0466

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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