Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0235 | 0.1161 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0963 | 0.1328 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.001 | 0.0001 | 0.0003 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0235 | 0.0324 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0001 | 0.5 |
Echinococcus granulosus | replication factor c subunit 1 | 0.001 | 0.0001 | 0.0003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0001 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0001 | 0.5 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0006 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.0156 | 0.0963 | 0.0963 | |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0001 | 0.5 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.007 | 0.0393 | 0.465 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0452 | 1 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0.0001 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0424 | 0.5021 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0452 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0001 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0235 | 0.2778 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0001 | 0.0007 |
Brugia malayi | hypothetical protein | 0.001 | 0.0001 | 0.0001 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.001 | 0.0001 | 0.0001 |
Schistosoma mansoni | DNA ligase IV | 0.001 | 0.0001 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0963 | 1 |
Brugia malayi | Cache domain containing protein | 0.0064 | 0.0354 | 0.0488 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0235 | 0.1161 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0235 | 0.1161 |
Brugia malayi | DKFZp564C0469 protein | 0.001 | 0.0001 | 0.0001 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0001 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0418 | 0.2683 | 0.5 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0001 | 0.0007 |
Schistosoma mansoni | serine-rich repeat protein | 0.0075 | 0.0424 | 0.5021 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0006 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0144 | 0.0883 | 0.4369 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0452 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0452 | 0.0623 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0317 | 0.2021 | 1 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0.0001 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.0747 | 0.7756 |
Echinococcus multilocularis | nibrin | 0.001 | 0.0001 | 0.0003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0235 | 0.2778 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0.0001 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0235 | 0.2436 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0006 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0317 | 0.2021 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.0747 | 0.103 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0418 | 0.2683 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0418 | 0.2683 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0418 | 0.2683 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0418 | 0.2683 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1112 | 0.725 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.001 | 0.0001 | 0.0001 | |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0418 | 0.2683 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0418 | 0.2683 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0452 | 0.5349 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0144 | 0.0883 | 0.4369 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0354 | 0.3674 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.0452 | 0.5349 |
Echinococcus granulosus | nibrin | 0.001 | 0.0001 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.0452 | 0.2234 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.001 | 0.0001 | 0.0001 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0.0001 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0418 | 0.2683 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0235 | 0.1161 |
Brugia malayi | topoisomerase | 0.001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.0452 | 0.2234 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0006 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0006 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.0747 | 0.7756 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.001 | 0.0001 | 0.0007 |
Brugia malayi | hypothetical protein | 0.001 | 0.0001 | 0.0001 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0001 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0235 | 0.2778 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0138 | 0.0844 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0001 | 0.0006 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.