Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.2025 | 0.603 | 1 |
Schistosoma mansoni | dihydroceramide desaturase | 0.1339 | 0.3318 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1828 | 0.5253 | 0.9313 |
Onchocerca volvulus | Matrilysin homolog | 0.1902 | 0.5546 | 1 |
Onchocerca volvulus | 0.1126 | 0.2477 | 0.2802 | |
Echinococcus multilocularis | adam | 0.0812 | 0.1235 | 0.1045 |
Loa Loa (eye worm) | disintegrin family protein | 0.0919 | 0.1658 | 0.275 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.1339 | 0.3318 | 0.3173 |
Brugia malayi | Hemopexin family protein | 0.1126 | 0.2477 | 0.2591 |
Schistosoma mansoni | tyrosine kinase | 0.0581 | 0.0321 | 0.035 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.1268 | 0.3035 | 0.2884 |
Schistosoma mansoni | tyrosine kinase | 0.0587 | 0.0345 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.1004 | 0.1993 | 0.3305 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.1339 | 0.3318 | 0.3173 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0824 | 0.1282 | 0.2127 |
Schistosoma mansoni | tyrosine kinase | 0.1093 | 0.2346 | 0.6868 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0587 | 0.0345 | 0.0136 |
Loa Loa (eye worm) | matrixin family protein | 0.1828 | 0.5253 | 0.8711 |
Loa Loa (eye worm) | hypothetical protein | 0.0824 | 0.1282 | 0.2127 |
Schistosoma mansoni | tyrosine kinase | 0.0587 | 0.0345 | 0.0429 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1004 | 0.1993 | 0.1581 |
Brugia malayi | Matrixin family protein | 0.0824 | 0.1282 | 0.0099 |
Loa Loa (eye worm) | matrixin family protein | 0.2025 | 0.603 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0812 | 0.1235 | 0.3292 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1004 | 0.1993 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.1085 | 0.2312 | 0.2145 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0665 | 0.0652 | 0.1414 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0587 | 0.0345 | 0.0136 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1093 | 0.2346 | 0.2317 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0824 | 0.1282 | 0.2127 |
Loa Loa (eye worm) | hypothetical protein | 0.0898 | 0.1575 | 0.2613 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0898 | 0.1575 | 0.4389 |
Schistosoma mansoni | tyrosine kinase | 0.0581 | 0.0321 | 0.035 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1093 | 0.2346 | 0.218 |
Echinococcus granulosus | adam | 0.0812 | 0.1235 | 0.1045 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1093 | 0.2346 | 0.389 |
Echinococcus multilocularis | adam 17 protease | 0.0665 | 0.0652 | 0.0449 |
Brugia malayi | Disintegrin family protein | 0.1339 | 0.3318 | 0.4345 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.097 | 0.1857 | 0.5295 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1004 | 0.1993 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1126 | 0.2477 | 0.7292 |
Loa Loa (eye worm) | reprolysin | 0.0554 | 0.0212 | 0.0352 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1093 | 0.2346 | 0.218 |
Brugia malayi | Matrixin family protein | 0.0824 | 0.1282 | 0.0099 |
Schistosoma mansoni | tyrosine kinase | 0.0581 | 0.0321 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.1548 | 0.4142 | 0.6869 |
Mycobacterium ulcerans | hydrolase | 0.1004 | 0.1993 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0824 | 0.1282 | 0.0099 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0587 | 0.0345 | 0.0136 |
Brugia malayi | Matrixin family protein | 0.0824 | 0.1282 | 0.0099 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.1268 | 0.3035 | 0.2884 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 3 % | Hypoglycemic activity in alloxan-diabetic female albino mice expressed as percentage reduction of plasma glucose levels | ChEMBL. | 6631920 |
Reduction (functional) | = 3 % | Hypoglycemic activity in alloxan-diabetic female albino mice expressed as percentage reduction of plasma glucose levels | ChEMBL. | 6631920 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.