Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0101 | 0.3607 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0101 | 0.3607 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0096 | 0.3127 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.011 | 0.4509 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0096 | 0.3127 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0096 | 0.3127 | 1 |
Giardia lamblia | Hypothetical protein | 0.0096 | 0.3127 | 0.5 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0096 | 0.3127 | 0.6935 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0096 | 0.3127 | 0.5 |
Leishmania major | silent information regulator 2, putative | 0.0096 | 0.3127 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0096 | 0.3127 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0096 | 0.3127 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0101 | 0.3607 | 0.3477 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0096 | 0.3127 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0096 | 0.3127 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0096 | 0.3127 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0096 | 0.3127 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0166 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.011 | 0.4509 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.