TDR Targets

Basic information

Technical information

TDR Targets ID: 650978
Name: 2-(2-bromophenoxy)-N-(5-propan-2-yl-1,3,4-thi adiazol-2-yl)acetamide
MW: 356.238 | Formula: C13H14BrN3O2S
H donors: 1 H acceptors: 3 LogP: 3.43 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1nnc(s1)C(C)C)COc1ccccc1Br
InChi: 1S/C13H14BrN3O2S/c1-8(2)12-16-17-13(20-12)15-11(18)7-19-10-6-4-3-5-9(10)14/h3-6,8H,7H2,1-2H3,(H,15,17,18)
InChiKey: AXJWQKGOTKSCJI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-bromophenoxy)-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)acetamide
2-(2-bromophenoxy)-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)ethanamide
ZINC00710176
Oprea1_125363
AF-399/15285139
Oprea1_098774
ST026809

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	transmembrane cation transporter	0.0071	0.0019	0.5
Schistosoma mansoni	hypothetical protein	0.2133	0.9226	0.9226
Echinococcus multilocularis	calcium activated potassium channel variant	0.0071	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.0071	0.0019	0.0019
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0071	0.0019	0.0019
Schistosoma mansoni	tyrosine kinase	0.0737	0.2994	0.2994
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus granulosus	twik family of potassium channels	0.0071	0.0019	0.0019
Brugia malayi	latrophilin 2 splice variant baaae	0.0143	0.0343	0.0343
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0071	0.0019	0.5
Echinococcus granulosus	microtubule associated protein 2	0.1377	0.585	0.585
Schistosoma mansoni	tyrosine kinase	0.2307	1	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0737	0.2994	0.2994
Echinococcus multilocularis		0.0714	0.2891	0.2891
Brugia malayi	Pre-SET motif family protein	0.0206	0.0626	0.0626
Schistosoma mansoni	calcium-activated potassium channel	0.1377	0.5848	0.5848
Brugia malayi	Protein kinase domain containing protein	0.0737	0.2994	0.2994
Onchocerca volvulus		0.0235	0.0753	1
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0071	0.0019	0.5
Brugia malayi	hypothetical protein	0.0146	0.0357	0.0357
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0136	0.0136
Toxoplasma gondii	ion channel protein	0.0071	0.0019	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0071	0.0019	0.0019
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0071	0.0019	0.0019
Echinococcus granulosus	potassium channel subfamily K	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0136	0.0136
Plasmodium vivax	potassium channel, putative	0.0071	0.0019	0.5
Toxoplasma gondii	ion channel protein	0.0071	0.0019	0.5
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0071	0.0019	0.0019
Schistosoma mansoni	tyrosine kinase	0.0737	0.2994	0.2994
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.0626	0.0626
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0071	0.0019	0.0019
Echinococcus multilocularis	neuropeptide receptor A26	0.1005	0.4189	0.4189
Echinococcus granulosus	epidermal growth factor receptor	0.2307	1	1
Echinococcus multilocularis	potassium channel subfamily K 8	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0686	0.2767	0.2767
Echinococcus multilocularis	twik family of potassium channels	0.0071	0.0019	0.0019
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0071	0.0019	0.0019
Echinococcus multilocularis	potassium channel subfamily K	0.0071	0.0019	0.0019
Loa Loa (eye worm)	TWK-28 protein	0.0071	0.0019	0.0019
Echinococcus multilocularis	twik family of potassium channels	0.0071	0.0019	0.0019
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0725	0.2942	0.2942
Schistosoma mansoni	microtubule-associated protein tau	0.1377	0.585	0.585
Schistosoma mansoni	hypothetical protein	0.0169	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Schistosoma mansoni	calcium-activated potassium channel	0.0071	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0071	0.0019	0.0019
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Schistosoma mansoni	calcium-activated potassium channel	0.0071	0.0019	0.0019
Echinococcus granulosus	epidermal growth factor receptor	0.1239	0.5236	0.5236
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0071	0.0019	0.0019
Echinococcus granulosus	geminin	0.0169	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0071	0.0019	0.0019
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.0753	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.2133	0.9226	0.9226
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0233	0.0743	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus multilocularis	epidermal growth factor receptor	0.1239	0.5236	0.5236
Leishmania major	hypothetical protein, conserved	0.0071	0.0019	0.5
Echinococcus multilocularis	geminin	0.0169	0.0459	0.0459
Onchocerca volvulus		0.0146	0.0357	0.4603
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Schistosoma mansoni	tyrosine kinase	0.1239	0.5236	0.5236
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0071	0.0019	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0136	0.0136
Plasmodium falciparum	potassium channel	0.0071	0.0019	0.5
Mycobacterium ulcerans	ion transport protein	0.0071	0.0019	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0071	0.0019	0.0019
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0071	0.0019	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0071	0.0019	0.0019
Loa Loa (eye worm)	TWK-7 protein	0.0071	0.0019	0.0019
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Giardia lamblia	Hypothetical protein	0.0071	0.0019	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.1239	0.5236	0.5236
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0071	0.0019	0.5
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0136	0.0136
Echinococcus granulosus	calcium activated potassium channel variant	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Leishmania major	potassium channel subunit-like protein	0.0071	0.0019	0.5
Schistosoma mansoni	tyrosine kinase	0.1226	0.5178	0.5178
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0136	0.0136
Echinococcus granulosus	potassium channel subfamily K 8	0.0071	0.0019	0.0019
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0071	0.0019	0.0019
Echinococcus multilocularis	tumor protein p63	0.0327	0.1164	0.1164
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0071	0.0019	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0136	0.0136
Echinococcus granulosus	insulin receptor	0.0737	0.2994	0.2994
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0785	0.3207	0.3207
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Plasmodium vivax	potassium channel, putative	0.0071	0.0019	0.5
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0071	0.0019	0.0019
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0233	0.0743	0.0743
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0019	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0737	0.2994	0.2994
Schistosoma mansoni	hypothetical protein	0.0169	0.0459	0.0459
Echinococcus granulosus	potassium channel subfamily K 8	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0357	0.0357
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0071	0.0019	0.0019
Schistosoma mansoni	tyrosine kinase	0.1239	0.5236	0.5236
Schistosoma mansoni	calcium-activated potassium channel	0.2133	0.9226	0.9226
Loa Loa (eye worm)	hypothetical protein	0.0651	0.261	0.261
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0071	0.0019	0.0019
Schistosoma mansoni	tyrosine kinase	0.1226	0.5178	0.5178
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus multilocularis	potassium channel subfamily K 8	0.0071	0.0019	0.0019
Leishmania major	ion transport protein-like protein	0.0071	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0071	0.0019	0.0019
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.0136	0.0136
Trypanosoma cruzi	ion transport protein, putative	0.0071	0.0019	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0376	0.1381	0.1381
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0209	0.0639	0.0639
Echinococcus granulosus	small conductance calcium activated potassium	0.2133	0.9226	0.9226
Loa Loa (eye worm)	TK/EGFR protein kinase	0.2307	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0209	0.0639	0.0639
Echinococcus multilocularis	epidermal growth factor receptor	0.2307	1	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0071	0.0019	0.0019
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0071	0.0019	0.5
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0071	0.0019	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0071	0.0019	0.0019
Echinococcus multilocularis	microtubule associated protein 2	0.1377	0.585	0.585
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0343	0.0343
Leishmania major	calcium/potassium channel (CAKC), putative	0.0071	0.0019	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0071	0.0019	0.0019
Echinococcus granulosus	twik family of potassium channels	0.0071	0.0019	0.0019
Loa Loa (eye worm)	TK/INSR protein kinase	0.0737	0.2994	0.2994
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0071	0.0019	0.0019
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0071	0.0019	0.0019
Echinococcus granulosus	neuropeptide receptor A26	0.1005	0.4189	0.4189
Plasmodium falciparum	potassium channel	0.0071	0.0019	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus granulosus	neuropeptide s receptor	0.1005	0.4189	0.4189
Loa Loa (eye worm)	uncoordinated protein 58	0.0071	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus multilocularis	neuropeptide s receptor	0.1005	0.4189	0.4189
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0019	0.5
Schistosoma mansoni	twik family of potassium channels-related	0.0071	0.0019	0.0019
Trypanosoma cruzi	ion transport protein, putative	0.0071	0.0019	0.5
Schistosoma mansoni	hypothetical protein	0.0143	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Schistosoma mansoni	tyrosine kinase	0.1226	0.5178	0.5178
Echinococcus multilocularis	insulin receptor	0.0737	0.2994	0.2994
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1381	0.1381
Leishmania major	hypothetical protein, conserved	0.0071	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019
Echinococcus granulosus	tumor protein p63	0.0327	0.1164	0.1164
Echinococcus multilocularis	small conductance calcium activated potassium	0.2133	0.9226	0.9226
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0071	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0019	0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 650978