Detailed information for compound 650996

Basic information

Technical information
  • TDR Targets ID: 650996
  • Name: (6Z)-6-[(3,4-dimethoxyphenyl)methylidene]-2-h eptyl-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimi din-7-one
  • MW: 414.521 | Formula: C21H26N4O3S
  • H donors: 0 H acceptors: 1 LogP: 5.19 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCc1nn2c(=NC(=O)C(=Cc3ccc(c(c3)OC)OC)C2=N)s1
  • InChi: 1S/C21H26N4O3S/c1-4-5-6-7-8-9-18-24-25-19(22)15(20(26)23-21(25)29-18)12-14-10-11-16(27-2)17(13-14)28-3/h10-13,22H,4-9H2,1-3H3/b15-12-,22-19?
  • InChiKey: YCQFUYHXDIIOGK-FDXKLOFQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[(3,4-dimethoxyphenyl)methylidene]-2-heptyl-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6Z)-6-[(3,4-dimethoxyphenyl)methylene]-2-heptyl-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • 6-[(3,4-dimethoxyphenyl)methylene]-2-heptyl-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • 6-(3,4-dimethoxybenzylidene)-2-heptyl-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6Z)-6-(3,4-dimethoxybenzylidene)-2-heptyl-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • A2797/0118216

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide receptor 0.0075 0.113 0.113
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Trichomonas vaginalis cyclin B, putative 0.0061 0.0872 0.6845
Trypanosoma cruzi CYC2-like cyclin, putative 0.0083 0.1274 1
Schistosoma mansoni hypothetical protein 0.0075 0.113 0.1997
Onchocerca volvulus 0.0075 0.113 0.887
Brugia malayi GnHR receptor homolog 0.0075 0.113 0.4227
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.113 0.113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Onchocerca volvulus 0.0075 0.113 0.887
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Brugia malayi neuropeptide F receptor 0.0075 0.113 0.4227
Brugia malayi Dopamine receptor protein 1 0.0075 0.113 0.4227
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0075 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Trypanosoma brucei cdc2-related kinase 3 0.008 0.1231 0.966
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.008 0.1231 0.966
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus granulosus cyclin dependent kinase 5 0.008 0.1231 0.1231
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0083 0.1274 0.2252
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Trypanosoma brucei mitotic cyclin 6 0.0083 0.1274 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Brugia malayi ORL1-like opioid receptor 0.0075 0.113 0.4227
Giardia lamblia G2/mitotic-specific cyclin B 0.0083 0.1274 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0075 0.113 0.113
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0243 0.0907
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.113 0.113
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.113 0.1997
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus multilocularis neuropeptide s receptor 0.0548 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0027
Echinococcus granulosus snurportin 1 0.0317 0.5657 0.5657
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.113 0.113
Echinococcus multilocularis neuropeptide receptor 0.0075 0.113 0.113
Echinococcus multilocularis serotonin receptor 0.0075 0.113 0.113
Echinococcus granulosus peptide allatostatin:somatostatin 0.0075 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0083 0.1274 0.2252
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.113 0.113
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0157 0.2673 0.2673
Echinococcus granulosus cyclins 0.0061 0.0872 0.0872
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0075 0.113 0.1997
Schistosoma mansoni opsin-like receptor 0.0075 0.113 0.1997
Schistosoma mansoni hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Brugia malayi G-protein coupled receptor 0.0075 0.113 0.4227
Echinococcus multilocularis cyclin dependent kinase 5 0.008 0.1231 0.1231
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0132 0.1034
Echinococcus granulosus cyclins 0.0061 0.0872 0.0872
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0047
Schistosoma mansoni biogenic amine receptor 0.0075 0.113 0.1997
Trichomonas vaginalis cyclin B, putative 0.0083 0.1274 1
Brugia malayi cell division control protein 2 homolog 0.008 0.1231 0.4604
Entamoeba histolytica cyclin family protein 0.0061 0.0872 0.6845
Loa Loa (eye worm) hypothetical protein 0.003 0.0279 0.0492
Schistosoma mansoni amine GPCR 0.0075 0.113 0.1997
Onchocerca volvulus 0.0075 0.113 0.887
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.038 0.142
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0075 0.113 0.113
Echinococcus multilocularis dro:myosuppressin receptor 0.0075 0.113 0.113
Brugia malayi putative neuropeptide receptor 0.0075 0.113 0.4227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus multilocularis cyclin dependent kinase 0.008 0.1231 0.1231
Brugia malayi Cyclin, N-terminal domain containing protein 0.0083 0.1274 0.4766
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.113 0.113
Echinococcus multilocularis GPCR, family 2 0.0016 0.0027 0.0027
Echinococcus granulosus fmrfamide receptor 0.0075 0.113 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0872 0.6845
Echinococcus multilocularis lamin dm0 0.0028 0.0243 0.0243
Echinococcus multilocularis serotonin receptor 0.0075 0.113 0.113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Onchocerca volvulus 0.0075 0.113 0.887
Schistosoma mansoni hypothetical protein 0.0035 0.038 0.0671
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Trichomonas vaginalis cyclins, putative 0.0083 0.1274 1
Echinococcus multilocularis cyclins 0.0061 0.0872 0.0872
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0243 0.0429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0132 0.0233
Brugia malayi RE15519p 0.0075 0.113 0.4227
Echinococcus granulosus cyclin B3 1 0.0061 0.0872 0.0872
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0173 0.1361
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0075 0.113 0.1997
Brugia malayi Dopamine receptor 0.0075 0.113 0.4227
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.113 0.113
Trichomonas vaginalis cyclins, putative 0.0036 0.0402 0.3155
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0075 0.113 0.113
Trichomonas vaginalis cyclin B, putative 0.0083 0.1274 1
Trichomonas vaginalis ran, putative 0.0022 0.0132 0.1034
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0075 0.113 0.113
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0035 0.038 0.0671
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0075 0.113 0.113
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.113 0.1997
Schistosoma mansoni neuropeptide receptor 0.0075 0.113 0.1997
Brugia malayi Tachykinin-like peptides receptor 99D 0.0075 0.113 0.4227
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0075 0.113 0.1997
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Entamoeba histolytica Ran family GTPase 0.0022 0.0132 0.1034
Echinococcus granulosus cyclin dependent kinase 0.008 0.1231 0.1231
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.113 0.113
Brugia malayi follicle stimulating hormone receptor 0.0075 0.113 0.4227
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Echinococcus multilocularis somatostatin receptor 0.0075 0.113 0.113
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0075 0.113 0.113
Entamoeba histolytica cell division protein kinase 2, putative 0.008 0.1231 0.966
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0132 0.1071
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0132 0.1071
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.113 0.113
Onchocerca volvulus 0.0028 0.0243 0.1904
Brugia malayi sulfakinin receptor protein 0.0075 0.113 0.4227
Trypanosoma cruzi cyclin 6, putative 0.0083 0.1274 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0075 0.113 0.887
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0075 0.113 0.887
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0027 0.01
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0173 0.1361
Echinococcus multilocularis cyclins 0.0061 0.0872 0.0872
Echinococcus granulosus cyclins 0.0061 0.0872 0.0872
Echinococcus granulosus alpha 1A adrenergic receptor 0.0075 0.113 0.113
Schistosoma mansoni hypothetical protein 0.0317 0.5657 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0684 0.2558
Trichomonas vaginalis cyclins, putative 0.0061 0.0872 0.6845
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0027
Echinococcus multilocularis cyclin B3 1 0.0061 0.0872 0.0872
Brugia malayi intermediate filament protein 0.0028 0.0243 0.0907
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Schistosoma mansoni neuropeptide receptor 0.0075 0.113 0.1997
Leishmania major cyclin 0.0083 0.1274 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0684 0.1209
Schistosoma mansoni ran 0.0022 0.0132 0.0233
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0051 0.0684 0.1209
Echinococcus multilocularis cyclins 0.0061 0.0872 0.0872
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.113 0.113
Trichomonas vaginalis CMGC family protein kinase 0.008 0.1231 0.966
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0132 0.1034
Echinococcus granulosus lamin 0.0028 0.0243 0.0243
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0075 0.113 0.113
Echinococcus multilocularis musashi 0.0028 0.0243 0.0243
Onchocerca volvulus 0.0075 0.113 0.887
Schistosoma mansoni importin beta-1 0.003 0.0279 0.0492
Echinococcus granulosus serotonin receptor 0.0075 0.113 0.113
Trichomonas vaginalis cyclin A, putative 0.0083 0.1274 1
Toxoplasma gondii hypothetical protein 0.0047 0.0595 0.4832
Entamoeba histolytica cyclin family protein 0.0061 0.0872 0.6845
Schistosoma mansoni lamin 0.0028 0.0243 0.0429
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0075 0.113 0.4227
Leishmania major importin beta-1 subunit, putative 0.0024 0.0173 0.1361
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0075 0.113 0.1997
Echinococcus granulosus cyclins 0.0061 0.0872 0.0872
Onchocerca volvulus 0.0075 0.113 0.887
Schistosoma mansoni neuropeptide receptor 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Plasmodium falciparum importin beta, putative 0.003 0.0279 0.2263
Schistosoma mansoni hypothetical protein 0.0174 0.299 0.5284
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0132 0.1071
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0075 0.113 0.113
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0075 0.113 0.1997
Schistosoma mansoni neuropeptide f receptor 76f 0.0075 0.113 0.1997
Schistosoma mansoni cyclin B 0.0083 0.1274 0.2252
Onchocerca volvulus 0.0083 0.1274 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.008 0.1231 0.2175
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0075 0.113 0.113
Giardia lamblia Cyclin A 0.0061 0.0872 0.6845
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0157 0.2673 0.2673
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0075 0.113 0.113
Echinococcus granulosus sex peptide receptor 0.0075 0.113 0.113
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0047
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0047
Echinococcus granulosus intermediate filament protein 0.0028 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Brugia malayi G protein-coupled receptor 0.0075 0.113 0.4227
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0132 0.1034
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0279 0.2186
Loa Loa (eye worm) TYRA-2 protein 0.0075 0.113 0.1997
Echinococcus granulosus GPCR family 2 0.0016 0.0027 0.0027
Schistosoma mansoni opsin-like receptor 0.0075 0.113 0.1997
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus multilocularis fmrfamide receptor 0.0075 0.113 0.113
Onchocerca volvulus 0.0075 0.113 0.887
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus granulosus orexin receptor type 2 0.0075 0.113 0.113
Brugia malayi larval opioid receptor 0.0075 0.113 0.4227
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Onchocerca volvulus 0.0075 0.113 0.887
Trichomonas vaginalis cyclins, putative 0.0083 0.1274 1
Echinococcus granulosus g protein coupled receptor 0.0075 0.113 0.113
Echinococcus multilocularis fmrfamide receptor 0.0075 0.113 0.113
Echinococcus multilocularis cyclins 0.0061 0.0872 0.0872
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.008 0.1231 1
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0047
Schistosoma mansoni lamin 0.0028 0.0243 0.0429
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.113 0.1997
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.113 0.113
Echinococcus multilocularis neuropeptide FF receptor 2 0.0075 0.113 0.113
Echinococcus multilocularis g protein coupled receptor 0.0075 0.113 0.113
Trichomonas vaginalis cyclin B, putative 0.0083 0.1274 1
Echinococcus multilocularis g-protein coupled receptor 0.0075 0.113 0.113
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0132 0.1034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus multilocularis sex peptide receptor 0.0075 0.113 0.113
Schistosoma mansoni ran 0.0022 0.0132 0.0233
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0173 0.1361
Schistosoma mansoni biogenic amine receptor 0.0075 0.113 0.1997
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.113 0.113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.113 0.1997
Onchocerca volvulus 0.0075 0.113 0.887
Onchocerca volvulus 0.0075 0.113 0.887
Echinococcus multilocularis lamin 0.0028 0.0243 0.0243
Echinococcus multilocularis cyclins 0.0061 0.0872 0.0872
Echinococcus multilocularis G-protein coupled receptor, putative 0.0075 0.113 0.113
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0075 0.113 0.1997
Brugia malayi Serotonin receptor 0.0075 0.113 0.4227
Trypanosoma cruzi cdc2-related kinase 3 0.008 0.1231 0.966
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus granulosus neuropeptide receptor A26 0.0548 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0075 0.113 0.113
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0243 0.0429
Echinococcus multilocularis cyclins 0.0061 0.0872 0.0872
Echinococcus multilocularis neuropeptide receptor A26 0.0548 1 1
Schistosoma mansoni amine GPCR 0.0075 0.113 0.1997
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Entamoeba histolytica hypothetical protein 0.0024 0.0173 0.1361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.113 0.113
Echinococcus granulosus importin subunit beta 1 0.003 0.0279 0.0279
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0083 0.1274 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Brugia malayi Serotonin receptor 0.0075 0.113 0.4227
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0075 0.113 0.4227
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0075 0.113 0.113
Echinococcus multilocularis G protein coupled receptor 139 0.0075 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.008 0.1215 0.2147
Entamoeba histolytica cyclin, putative 0.0083 0.1274 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0157 0.2673 0.4725
Giardia lamblia Kinase, CMGC CDK 0.008 0.1231 0.966
Echinococcus granulosus hypothetical protein 0.0075 0.113 0.113
Echinococcus granulosus cyclins 0.0061 0.0872 0.0872
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus multilocularis cyclin b3 0.0061 0.0872 0.0872
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.113 0.1997
Onchocerca volvulus 0.0075 0.113 0.887
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.113 0.1997
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0075 0.113 0.1997
Brugia malayi Cyclin, N-terminal domain containing protein 0.0083 0.1274 0.4766
Plasmodium vivax protein kinase Crk2 0.008 0.1231 1
Trypanosoma cruzi cyclin, putative 0.0083 0.1274 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus multilocularis allatostatin A receptor 0.0075 0.113 0.113
Echinococcus granulosus dro:myosuppressin receptor 0.0075 0.113 0.113
Trichomonas vaginalis CMGC family protein kinase 0.008 0.1231 0.966
Schistosoma mansoni amine GPCR 0.0075 0.113 0.1997
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.113 0.113
Trypanosoma cruzi cdc2-related kinase 1 0.008 0.1231 0.966
Entamoeba histolytica cell division protein kinase 2, putative 0.008 0.1231 0.966
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.008 0.1231 0.966
Echinococcus granulosus G protein coupled receptor 139 0.0075 0.113 0.113
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.113 0.1997
Trichomonas vaginalis cyclin B3, putative 0.0061 0.0872 0.6845
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Schistosoma mansoni histamine h1 receptor 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0027 0.0233 0.0412
Echinococcus granulosus neuropeptide receptor 0.0075 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0684 0.2558
Schistosoma mansoni hypothetical protein 0.0075 0.113 0.1997
Echinococcus granulosus cyclin b3 0.0061 0.0872 0.0872
Brugia malayi putative neuropeptide receptor NPR1 0.0075 0.113 0.4227
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0075 0.113 0.1997
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0075 0.113 0.4227
Brugia malayi Dopamine receptor protein 2 0.0075 0.113 0.4227
Trichomonas vaginalis cyclin B, putative 0.0083 0.1274 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Giardia lamblia Hypothetical protein 0.0061 0.0872 0.6845
Schistosoma mansoni hypothetical protein 0.0075 0.113 0.1997
Plasmodium falciparum protein kinase 5 0.008 0.1231 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.113 0.113
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.008 0.1231 0.1231
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0075 0.113 0.4227
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.113 0.113
Echinococcus multilocularis snurportin 1 0.0317 0.5657 0.5657
Trichomonas vaginalis cyclin D, putative 0.0061 0.0872 0.6845
Brugia malayi G protein-coupled receptor F59B2.13 0.0075 0.113 0.4227
Brugia malayi Protein kinase domain containing protein 0.008 0.1231 0.4604
Loa Loa (eye worm) hypothetical protein 0.0028 0.0243 0.0429
Echinococcus granulosus g protein coupled receptor 0.0075 0.113 0.113
Trichomonas vaginalis cyclins, putative 0.0083 0.1274 1
Onchocerca volvulus 0.0075 0.113 0.887
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0132 0.0132
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.113 0.1997
Trichomonas vaginalis cyclin D, putative 0.0061 0.0872 0.6845
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0075 0.113 0.1997
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0173 0.1361
Trichomonas vaginalis CMGC family protein kinase 0.008 0.1231 0.966
Schistosoma mansoni myosin xvIII 0.0075 0.113 0.1997
Echinococcus multilocularis cyclin dependent kinase 1 0.008 0.1231 0.1231
Onchocerca volvulus 0.0075 0.113 0.887
Plasmodium vivax importin-beta 2, putative 0.003 0.0279 0.2263
Schistosoma mansoni opsin-like receptor 0.0075 0.113 0.1997
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0279 0.2263
Schistosoma mansoni growth hormone secretagogue receptor 0.0075 0.113 0.1997
Echinococcus multilocularis g protein coupled receptor 0.0075 0.113 0.113
Trypanosoma cruzi cdc2-related kinase 1 0.008 0.1231 0.966
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus multilocularis g protein coupled receptor 0.0075 0.113 0.113
Brugia malayi RNA, U transporter 1 0.0084 0.1304 0.4876
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.113 0.1997
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0027 0.01
Echinococcus granulosus g-protein coupled receptor 0.0075 0.113 0.113
Schistosoma mansoni cyclins 0.0061 0.0872 0.1541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.008 0.1231 0.2175
Echinococcus granulosus 7tm_1 domain containing protein 0.0075 0.113 0.113
Echinococcus multilocularis geminin 0.0174 0.299 0.299
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Schistosoma mansoni biogenic amine receptor 0.0075 0.113 0.1997
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus multilocularis cyclins 0.0061 0.0872 0.0872
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus multilocularis importin subunit beta 1 0.003 0.0279 0.0279
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.113 0.113
Leishmania major GTP-binding protein, putative 0.0022 0.0132 0.1034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Schistosoma mansoni hypothetical protein 0.0174 0.299 0.5284
Onchocerca volvulus 0.0075 0.113 0.887
Brugia malayi neuropeptide F receptor 0.0075 0.113 0.4227
Echinococcus granulosus tachykinin peptides receptor 99D 0.0075 0.113 0.113
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0075 0.113 0.113
Echinococcus multilocularis orexin receptor type 2 0.0075 0.113 0.113
Echinococcus granulosus cyclin dependent kinase 1 0.008 0.1231 0.1231
Onchocerca volvulus 0.0075 0.113 0.887
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0075 0.113 0.1997
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.5657 1
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.113 0.113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.113 0.1997
Plasmodium falciparum cyclin 0.0061 0.0872 0.7086
Loa Loa (eye worm) melatonin receptor type 1A 0.0075 0.113 0.1997
Echinococcus granulosus allatostatin A receptor 0.0075 0.113 0.113
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1231 0.2175
Onchocerca volvulus 0.0028 0.0243 0.1904
Schistosoma mansoni alpha-1 adrenergic receptor 0.0075 0.113 0.1997
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.113 0.113
Echinococcus multilocularis cyclin B 0.0083 0.1274 0.1274
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0027 0.0047
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.008 0.1231 0.2175
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Schistosoma mansoni amine GPCR 0.0075 0.113 0.1997
Entamoeba histolytica cyclin, putative 0.0061 0.0872 0.6845
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0075 0.113 0.1997
Schistosoma mansoni neuropeptide receptor 0.0075 0.113 0.1997
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1231 0.2175
Echinococcus granulosus 7TM GPCR rhodopsin 0.0075 0.113 0.113
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.113 0.113
Echinococcus granulosus cyclin B 0.0083 0.1274 0.1274
Trypanosoma cruzi cyclin, putative 0.0083 0.1274 1
Brugia malayi G-protein coupled receptor 0.0075 0.113 0.4227
Echinococcus granulosus geminin 0.0174 0.299 0.299
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0004
Echinococcus granulosus neuropeptide receptor 0.0075 0.113 0.113
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0132 0.0493
Onchocerca volvulus 0.0075 0.113 0.887
Brugia malayi Cyclin, N-terminal domain containing protein 0.0157 0.2673 1
Trypanosoma cruzi cdc2-related kinase 3 0.008 0.1231 0.966
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Echinococcus granulosus lamin dm0 0.0028 0.0243 0.0243
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.113 0.1997
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.113 0.113
Onchocerca volvulus 0.0075 0.113 0.887
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Schistosoma mansoni intermediate filament proteins 0.0028 0.0243 0.0429
Echinococcus granulosus g protein coupled receptor 0.0075 0.113 0.113
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.113 0.113
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0279 0.2186
Echinococcus granulosus somatostatin receptor 0.0075 0.113 0.113
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0002
Brugia malayi Melatonin receptor type 1A 0.0075 0.113 0.4227
Echinococcus multilocularis cyclin dependent kinase 1 0.008 0.1231 0.1231
Schistosoma mansoni adenoreceptor 0.0075 0.113 0.1997
Brugia malayi AKH receptor 0.0075 0.113 0.4227
Giardia lamblia Kinase, CMGC CDK 0.008 0.1231 0.966
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0075 0.113 0.1997
Brugia malayi Importin beta-1 subunit 0.003 0.0279 0.1042
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0075 0.113 0.4227
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.113 0.113
Schistosoma mansoni amine GPCR 0.0075 0.113 0.1997
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.113 0.113
Schistosoma mansoni cyclin B3 0.0157 0.2673 0.4725
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.113 0.1997
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Trichomonas vaginalis cyclins, putative 0.0083 0.1274 1
Brugia malayi hypothetical protein 0.0075 0.113 0.4227
Loa Loa (eye worm) hypothetical protein 0.0075 0.113 0.1997
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.113 0.1997
Trypanosoma brucei cdc2-related kinase 1 0.008 0.1231 0.966

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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