Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0031 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0312 | 0.4919 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0312 | 0.4919 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0031 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0031 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0031 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0312 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0548 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0603 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0603 | 1 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0548 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0031 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0548 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0031 | 0.099 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0031 | 0.099 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0031 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0031 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0603 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0031 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0603 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0031 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0031 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0031 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0017 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0031 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.