Detailed information for compound 655769

Basic information

Technical information
  • TDR Targets ID: 655769
  • Name: N-(2,4-dimethylphenyl)-2-(2-methyl-9-oxoacrid in-10-yl)acetamide
  • MW: 370.444 | Formula: C24H22N2O2
  • H donors: 1 H acceptors: 2 LogP: 5.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C)NC(=O)Cn1c2ccccc2c(=O)c2c1ccc(c2)C
  • InChi: 1S/C24H22N2O2/c1-15-8-10-20(17(3)12-15)25-23(27)14-26-21-7-5-4-6-18(21)24(28)19-13-16(2)9-11-22(19)26/h4-13H,14H2,1-3H3,(H,25,27)
  • InChiKey: GFIZOLZVUKIWDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,4-dimethylphenyl)-2-(2-methyl-9-oxo-acridin-10-yl)acetamide
  • N-(2,4-dimethylphenyl)-2-(2-methyl-9-oxo-10-acridinyl)acetamide
  • N-(2,4-dimethylphenyl)-2-(9-keto-2-methyl-acridin-10-yl)acetamide
  • N-(2,4-dimethylphenyl)-2-(2-methyl-9-oxo-acridin-10-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0229 0.5
Schistosoma mansoni hypothetical protein 0.0095 0.2278 0.328
Leishmania major pyruvate kinase 0.0033 0.0229 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.7231 0.7934
Echinococcus multilocularis pyruvate kinase 0.0033 0.0229 0.0229
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.5918 0.6446
Loa Loa (eye worm) RNA binding protein 0.0126 0.3306 0.3486
Leishmania major pyruvate kinase 0.0033 0.0229 0.5
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3306 0.4927
Echinococcus granulosus GPCR family 2 0.0095 0.2278 0.2096
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.3306 0.3486
Echinococcus granulosus neuropeptide receptor 0.0221 0.6475 0.6392
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.2278 0.2321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0723 0.0791
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3306 0.4927
Onchocerca volvulus 0.0048 0.073 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0723 0.0723
Brugia malayi RNA binding protein 0.0126 0.3306 0.3486
Echinococcus multilocularis G protein coupled receptor 139 0.0221 0.6475 0.6475
Loa Loa (eye worm) TAR-binding protein 0.0126 0.3306 0.3486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0299 0.9055 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3306 0.4927
Echinococcus multilocularis pyruvate kinase 0.0033 0.0229 0.0229
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0723 0.056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0723 0.0791
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0229 0.5
Schistosoma mansoni hypothetical protein 0.0095 0.2278 0.328
Schistosoma mansoni hypothetical protein 0.0095 0.2278 0.328
Schistosoma mansoni hypothetical protein 0.0205 0.5918 0.9109
Schistosoma mansoni hypothetical protein 0.0095 0.2278 0.328
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.2278 0.2278
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0229 0.5
Loa Loa (eye worm) hypothetical protein 0.0205 0.5918 0.6446
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0229 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0723 0.0791
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0229 0.5
Plasmodium falciparum pyruvate kinase 0.0033 0.0229 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0723 0.0506
Brugia malayi MH2 domain containing protein 0.0244 0.7231 0.7934
Chlamydia trachomatis pyruvate kinase 0.0033 0.0229 0.5
Echinococcus multilocularis tumor protein p63 0.0328 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.3306 0.3486
Loa Loa (eye worm) hypothetical protein 0.0095 0.2278 0.2321
Giardia lamblia Pyruvate kinase 0.0033 0.0229 0.5
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3306 0.4927
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0229 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.2278 0.2321
Loa Loa (eye worm) hypothetical protein 0.0299 0.9055 1
Echinococcus multilocularis tar DNA binding protein 0.0126 0.3306 0.3306
Loa Loa (eye worm) hypothetical protein 0.0048 0.073 0.0567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0723 0.0506
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.073 0.0802
Brugia malayi Latrophilin receptor protein 2 0.0095 0.2278 0.2321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0723 0.0723
Echinococcus multilocularis neuropeptide receptor 0.0221 0.6475 0.6475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0299 0.9055 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3306 0.4927
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.2278 0.2096
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0229 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.2278 0.2278
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0299 0.9055 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0229 0.5
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0229 0.5
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0229 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0723 0.056
Brugia malayi TAR-binding protein 0.0126 0.3306 0.3486
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.7231 0.7934
Echinococcus granulosus tar DNA binding protein 0.0126 0.3306 0.3149
Schistosoma mansoni neuropeptide receptor 0.0221 0.6475 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0229 0.5
Echinococcus multilocularis GPCR, family 2 0.0095 0.2278 0.2278
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.2278 0.2096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.