Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0089 | 0.0725 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0245 | 0.4225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Onchocerca volvulus | Peroxidasin homolog | 0.0089 | 0.0725 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0089 | 0.0725 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0127 | 0.1568 | 0.3711 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0245 | 0.4225 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0245 | 0.4225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Schistosoma mansoni | hypothetical protein | 0.0245 | 0.4225 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.0302 | 0.0279 |
Echinococcus multilocularis | insulin receptor | 0.0127 | 0.1568 | 0.3677 |
Brugia malayi | Blistered cuticle protein 3 | 0.0089 | 0.0725 | 0.0704 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0089 | 0.0725 | 0.1671 |
Onchocerca volvulus | 0.0089 | 0.0725 | 0.5 | |
Brugia malayi | Sugar transporter family protein | 0.0245 | 0.4225 | 0.4212 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0089 | 0.0725 | 0.1671 |
Echinococcus granulosus | peroxidasin | 0.0089 | 0.0725 | 0.1671 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0245 | 0.4225 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0245 | 0.4225 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0089 | 0.0725 | 0.1671 |
Brugia malayi | Animal haem peroxidase family protein | 0.0089 | 0.0725 | 0.0704 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Loa Loa (eye worm) | sugar transporter | 0.0245 | 0.4225 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0127 | 0.1568 | 0.3677 |
Onchocerca volvulus | Peroxidase homolog | 0.0089 | 0.0725 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0089 | 0.0725 | 0.1671 |
Onchocerca volvulus | 0.0089 | 0.0725 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0023 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0245 | 0.4225 | 1 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0725 | 0.0704 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0245 | 0.4225 | 1 |
Onchocerca volvulus | 0.0089 | 0.0725 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0089 | 0.0725 | 0.1716 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Schistosoma mansoni | glucose transport protein | 0.0245 | 0.4225 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0127 | 0.1568 | 0.3677 |
Echinococcus granulosus | insulin receptor | 0.0127 | 0.1568 | 0.3677 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0245 | 0.4225 | 1 |
Echinococcus multilocularis | General substrate transporter | 0.0221 | 0.3685 | 0.8715 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Plasmodium vivax | hexose transporter | 0.0245 | 0.4225 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0245 | 0.4225 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0089 | 0.0725 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0023 | 0.0054 |
Brugia malayi | Animal haem peroxidase family protein | 0.0089 | 0.0725 | 0.0704 |
Schistosoma mansoni | tyrosine kinase | 0.0127 | 0.1568 | 0.3711 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0127 | 0.1568 | 0.3677 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0089 | 0.0725 | 0.1671 |
Echinococcus granulosus | General substrate transporter | 0.0221 | 0.3685 | 0.8715 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Brugia malayi | Animal haem peroxidase family protein | 0.0089 | 0.0725 | 0.0704 |
Brugia malayi | Animal haem peroxidase family protein | 0.0089 | 0.0725 | 0.0704 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0279 | 0.0609 |
Schistosoma mansoni | glucose transport protein | 0.0245 | 0.4225 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0089 | 0.0725 | 0.0704 |
Echinococcus multilocularis | peroxidasin | 0.0089 | 0.0725 | 0.1671 |
Brugia malayi | Protein kinase domain containing protein | 0.0127 | 0.1568 | 0.1549 |
Plasmodium falciparum | hexose transporter | 0.0245 | 0.4225 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Brugia malayi | Peroxidasin | 0.0089 | 0.0725 | 0.0704 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0245 | 0.4225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Schistosoma mansoni | peroxidasin | 0.0089 | 0.0725 | 0.1716 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0023 | 0.0054 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0089 | 0.0725 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0725 | 0.1671 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0245 | 0.4225 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.834 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.777 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.773 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.722 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.711 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.678 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.649 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.588 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.496 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.193 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.