Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.036 | 0.036 |
Onchocerca volvulus | 0.0135 | 0.113 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0287 | 0.4318 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0135 | 0.113 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0557 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0557 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0557 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0557 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0557 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0135 | 0.113 | 0.113 |
Onchocerca volvulus | 0.0135 | 0.113 | 1 | |
Onchocerca volvulus | 0.0135 | 0.113 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0557 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0557 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0319 | 0.5001 | 0.5001 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0098 | 0.036 | 0.036 |
Giardia lamblia | Cathepsin B precursor | 0.0287 | 0.4318 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Onchocerca volvulus | 0.0135 | 0.113 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0135 | 0.113 | 0.08 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0135 | 0.113 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0557 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0287 | 0.4318 | 0.4318 |
Loa Loa (eye worm) | cysteine protease | 0.0135 | 0.113 | 0.08 |
Echinococcus granulosus | cathepsin l1 | 0.0098 | 0.036 | 0.036 |
Plasmodium vivax | vivapain-2 | 0.0135 | 0.113 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0287 | 0.4318 | 0.8633 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.113 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0135 | 0.113 | 0.113 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.113 | 0.113 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0135 | 0.113 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Onchocerca volvulus | 0.0135 | 0.113 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0135 | 0.113 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0098 | 0.036 | 0.3182 |
Loa Loa (eye worm) | ctsf protein | 0.0135 | 0.113 | 0.08 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Leishmania major | cathepsin L-like protease | 0.0319 | 0.5001 | 1 |
Onchocerca volvulus | 0.0135 | 0.113 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0319 | 0.5001 | 0.5001 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0283 | 0.4231 | 0.4231 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0135 | 0.113 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0229 | 0.31 | 0.31 |
Echinococcus multilocularis | cysteine protease | 0.0135 | 0.113 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.036 | 0.0833 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0135 | 0.113 | 0.113 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0135 | 0.113 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0135 | 0.113 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.036 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.113 | 0.08 |
Onchocerca volvulus | Cathepsin F homolog | 0.0135 | 0.113 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0135 | 0.113 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0135 | 0.113 | 0.113 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0319 | 0.5001 | 0.5001 |
Echinococcus granulosus | cathepsin l1 | 0.0135 | 0.113 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0287 | 0.4318 | 0.8234 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Plasmodium vivax | vivapain-2 | 0.0135 | 0.113 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Giardia lamblia | Cathepsin B precursor | 0.0287 | 0.4318 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0135 | 0.113 | 0.08 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.036 | 0.036 |
Onchocerca volvulus | Cathepsin L homolog | 0.0135 | 0.113 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0135 | 0.113 | 0.113 |
Onchocerca volvulus | 0.0135 | 0.113 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.113 | 0.113 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.113 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0135 | 0.113 | 0.113 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0319 | 0.5001 | 0.5001 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.113 | 0.113 |
Loa Loa (eye worm) | cathepsin B | 0.0287 | 0.4318 | 0.4106 |
Giardia lamblia | Cathepsin B precursor | 0.0287 | 0.4318 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0287 | 0.4318 | 0.4318 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Loa Loa (eye worm) | fibroinase | 0.0135 | 0.113 | 0.08 |
Echinococcus granulosus | cathepsin b | 0.0557 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0135 | 0.113 | 1 |
Toxoplasma gondii | cathepsin B | 0.0287 | 0.4318 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0135 | 0.113 | 0.113 |
Onchocerca volvulus | Cathepsin L homolog | 0.0135 | 0.113 | 1 |
Leishmania major | cathepsin L-like protease | 0.0319 | 0.5001 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0135 | 0.113 | 0.113 |
Brugia malayi | cathepsin L-like precursor | 0.0098 | 0.036 | 0.036 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0319 | 0.5001 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.113 | 0.113 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0098 | 0.036 | 0.036 |
Leishmania major | cathepsin L-like protease | 0.0319 | 0.5001 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.113 | 0.2618 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | 0 % | Percent reduction of edema in rat on 23rd day after oral administration of 20 mg/kg in antiarthritis assay; i = Inactive | ChEMBL. | 6606043 |
Reduction (functional) | = 12.5 % | Percent reduction of edema in mice 3h after oral administration of 20 mg/kg in carrageenin model | ChEMBL. | 6606043 |
Reduction (functional) | = 12.5 % | Percent reduction of edema in mice 3h after oral administration of 20 mg/kg in carrageenin model | ChEMBL. | 6606043 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.