Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.8868 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.4312 | 0.3965 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4312 | 0.4312 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.4312 | 0.4312 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.4312 | 0.3965 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0609 | 0.053 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.8868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0609 | 0.053 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0609 | 0.053 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.4312 | 0.4484 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.8868 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0609 | 0.053 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0575 | 0.0575 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.4312 | 0.4776 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.5653 | 0.5388 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0609 | 0.0037 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.8868 | 0.8868 |
Echinococcus multilocularis | lamin | 0.0028 | 0.4312 | 0.4776 |
Echinococcus granulosus | lamin | 0.0028 | 0.4312 | 0.4776 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.8868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.4312 | 0.4312 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.8868 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.8868 | 0.8799 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4165 | 0.4165 |
Schistosoma mansoni | lamin | 0.0028 | 0.4312 | 0.4484 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.4312 | 0.4776 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.8868 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.5653 | 0.6108 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0609 | 0.053 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.8868 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0609 | 0.053 |
Schistosoma mansoni | lamin | 0.0028 | 0.4312 | 0.4484 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0609 | 0.0037 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.4312 | 0.4776 |
Onchocerca volvulus | 0.0028 | 0.4312 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0028 | 0.4312 | 0.4776 |
Onchocerca volvulus | 0.0028 | 0.4312 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0147 | 0.0147 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.