Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 0.505 | 0.505 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1119 | 0.7372 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1511 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1119 | 0.7372 | 0.7372 |
Loa Loa (eye worm) | hypothetical protein | 0.1511 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1119 | 0.7372 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1119 | 0.7372 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1119 | 0.7372 | 0.7372 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1119 | 0.7372 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1511 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1511 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.