Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0706 | 0.0696 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0034 | 0.0706 | 0.0696 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0028 | 0.0559 | 0.0524 |
Onchocerca volvulus | Putative endochitinase | 0.0262 | 0.6041 | 0.6817 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0034 | 0.0706 | 0.0696 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.0028 | 0.0559 | 0.0521 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1529 | 0.1465 |
Onchocerca volvulus | Putative endochitinase | 0.0233 | 0.538 | 0.5995 |
Schistosoma mansoni | hypothetical protein | 0.043 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0608 | 0.006 | |
Schistosoma mansoni | chitinase | 0.0034 | 0.0706 | 0.0706 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0371 | 0.8601 | 0.8591 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.1529 | 0.1666 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1529 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0608 | 0.0577 |
Brugia malayi | Endochitinase | 0.0034 | 0.0706 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0842 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.4573 | 0.5251 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.8601 | 1 |
Echinococcus multilocularis | Glycoside hydrolase, chitinase domain containing protein 1 | 0.0034 | 0.0706 | 0.0636 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.0028 | 0.0559 | 0.0521 |
Loa Loa (eye worm) | glycosyl hydrolase family 18 protein | 0.0034 | 0.0706 | 0.0693 |
Onchocerca volvulus | Putative endochitinase | 0.0262 | 0.6041 | 0.6817 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0706 | 0.0696 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0371 | 0.8601 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0842 | 0.0773 |
Trichomonas vaginalis | chitinase, putative | 0.0034 | 0.0706 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0608 | 0.0581 |
Loa Loa (eye worm) | chitinase I | 0.0233 | 0.538 | 0.6203 |
Plasmodium falciparum | conserved protein, unknown function | 0.0371 | 0.8601 | 1 |
Brugia malayi | endochitinase | 0.0233 | 0.538 | 0.6204 |
Toxoplasma gondii | hypothetical protein | 0.0371 | 0.8601 | 1 |
Leishmania major | chitinase | 0.0233 | 0.538 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0648 | 0.0648 |
Onchocerca volvulus | Putative endochitinase | 0.0262 | 0.6041 | 0.6817 |
Plasmodium vivax | hypothetical protein, conserved | 0.0371 | 0.8601 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0064 | 0.1403 | 0.1403 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0028 | 0.0559 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Onchocerca volvulus | Putative endochitinase | 0.0233 | 0.538 | 0.5995 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1529 | 0.1465 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0233 | 0.538 | 0.6203 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0648 | 0.0648 |
Entamoeba histolytica | chitinase, putative | 0.0233 | 0.538 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0648 | 0.0578 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1529 | 0.1663 |
Onchocerca volvulus | 0.0371 | 0.8601 | 1 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Brugia malayi | Endochitinase | 0.0262 | 0.6041 | 0.6983 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0199 | 0.4573 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Mycobacterium tuberculosis | Possible chitinase | 0.0199 | 0.4573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.8601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0559 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0706 | 0.0693 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0608 | 0.0608 |
Onchocerca volvulus | Putative chitinase | 0.0034 | 0.0706 | 0.0182 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1529 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0371 | 0.8601 | 0.8601 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0648 | 0.0578 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1529 | 0.1529 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.1529 | 0.176 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0028 | 0.0559 | 0.0524 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0199 | 0.4573 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.043 | 1 | 1 |
Onchocerca volvulus | 0.0371 | 0.8601 | 1 | |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0371 | 0.8601 | 0.8591 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1529 | 0.5 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0028 | 0.0559 | 0.0524 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0227 | 0.5234 | 0.6031 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0706 | 0.0693 |
Echinococcus granulosus | Glycoside hydrolase chitinase domain containing protein 1 | 0.0034 | 0.0706 | 0.0636 |
Onchocerca volvulus | Putative endochitinase | 0.0034 | 0.0706 | 0.0182 |
Brugia malayi | endochitinase | 0.0262 | 0.6041 | 0.6983 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.