Detailed information for compound 662024

Basic information

Technical information
  • TDR Targets ID: 662024
  • Name: N'-(2-ethoxyphenyl)-N-[(2-methylphenyl)methyl ]oxamide
  • MW: 312.363 | Formula: C18H20N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)C(=O)NCc1ccccc1C
  • InChi: 1S/C18H20N2O3/c1-3-23-16-11-7-6-10-15(16)20-18(22)17(21)19-12-14-9-5-4-8-13(14)2/h4-11H,3,12H2,1-2H3,(H,19,21)(H,20,22)
  • InChiKey: GNTDBYOEQAOMTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(2-ethoxyphenyl)-N-(2-methylbenzyl)oxamide
  • N'-(2-ethoxyphenyl)-N-[(2-methylphenyl)methyl]ethanediamide
  • ZINC02812291
  • STK165220

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0117 0.5206 0.5206
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.5206 0.4941
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.4643 0.4326
Onchocerca volvulus 0.0208 1 1
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0208 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.3868 0.3529
Giardia lamblia Kinase, PLK 0.0091 0.3868 0.3505
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.2359 0.3882
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.2359 0.3882
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.3868 0.7923
Loa Loa (eye worm) hypothetical protein 0.0033 0.0805 0.0298
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.4643 0.4347
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0559 1
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.4643 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 1 1
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.3887 0.7976
Loa Loa (eye worm) hypothetical protein 0.006 0.2192 0.1761
Brugia malayi 6-phosphofructokinase 0.0106 0.4643 0.4643
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 1 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.3887 0.7976
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0559 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0805 0.0805
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.4643 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.4643 0.4347
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0208 1 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.4643 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1619 0.1156
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0559 1
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.4643 1
Schistosoma mansoni transient receptor potential channel 0.0063 0.2359 0.4049
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0559 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.4054 0.8423
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1619 0.1619
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1433 0.0926
Brugia malayi phosphofructokinase 0.0106 0.4643 0.4643
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.3868 0.8118
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.2359 0.3882
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.4643 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 1 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.4643 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0559 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.3868 0.3868
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0144 0.6624 1
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.2423 0.4612
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.2423 0.4612
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.3868 0.798
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.4054 0.8423
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0559 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0909 0.0909
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.3868 0.7923
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0064 0.2423 0.4612
Loa Loa (eye worm) hypothetical protein 0.0035 0.0909 0.0408
Loa Loa (eye worm) hypothetical protein 0.0095 0.4054 0.3726
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.4643 0.4326
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1619 0.1619
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.4054 0.8466
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.4643 0.4326
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.2423 0.1975
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.4643 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0208 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.3868 0.8118
Leishmania major hypothetical protein, conserved 0.0064 0.2423 0.4612
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.4643 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.3868 0.8118
Schistosoma mansoni transient receptor potential channel 0.0095 0.4054 0.8466
Schistosoma mansoni transient receptor potential channel 0.0063 0.2359 0.4049
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0559 0.5
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.2359 0.3882
Trypanosoma brucei polo-like protein kinase 0.0091 0.3868 0.8118
Loa Loa (eye worm) phosphofructokinase 0.0106 0.4643 0.4347
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1433 0.0926
Schistosoma mansoni kinase 0.0046 0.1497 0.1803
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0559 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0742 0.0231
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.3868 0.3505
Brugia malayi 6-phosphofructokinase 0.0106 0.4643 0.4643
Loa Loa (eye worm) hypothetical protein 0.0049 0.1619 0.1156
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.2423 0.1975
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.4643 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0559 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.5206 0.4941
Brugia malayi hypothetical protein 0.0028 0.0523 0.0523

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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