Detailed information for compound 662024

Basic information

Technical information
  • TDR Targets ID: 662024
  • Name: N'-(2-ethoxyphenyl)-N-[(2-methylphenyl)methyl ]oxamide
  • MW: 312.363 | Formula: C18H20N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)C(=O)NCc1ccccc1C
  • InChi: 1S/C18H20N2O3/c1-3-23-16-11-7-6-10-15(16)20-18(22)17(21)19-12-14-9-5-4-8-13(14)2/h4-11H,3,12H2,1-2H3,(H,19,21)(H,20,22)
  • InChiKey: GNTDBYOEQAOMTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(2-ethoxyphenyl)-N-(2-methylbenzyl)oxamide
  • N'-(2-ethoxyphenyl)-N-[(2-methylphenyl)methyl]ethanediamide
  • ZINC02812291
  • STK165220

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0117 0.5206 0.5206
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.4643 1
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0064 0.2423 0.4612
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.4643 0.4326
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.3868 0.8118
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.4643 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.4643 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.3868 0.7923
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Schistosoma mansoni kinase 0.0046 0.1497 0.1803
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.3868 0.798
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.4643 0.4347
Loa Loa (eye worm) hypothetical protein 0.0095 0.4054 0.3726
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0208 1 1
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.4054 0.8466
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0805 0.0805
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.4643 0.5
Schistosoma mansoni transient receptor potential channel 0.0063 0.2359 0.4049
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 1 1
Schistosoma mansoni transient receptor potential channel 0.0063 0.2359 0.4049
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.3868 0.8118
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Onchocerca volvulus 0.0208 1 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1433 0.0926
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.4643 1
Loa Loa (eye worm) hypothetical protein 0.006 0.2192 0.1761
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0208 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.2359 0.3882
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.3868 0.8118
Loa Loa (eye worm) hypothetical protein 0.0049 0.1619 0.1156
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.2359 0.3882
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.3868 0.3868
Loa Loa (eye worm) hypothetical protein 0.0035 0.0909 0.0408
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.3868 0.7923
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.5206 0.4941
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0909 0.0909
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 1 1
Schistosoma mansoni transient receptor potential channel 0.0095 0.4054 0.8466
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1433 0.0926
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.4643 1
Brugia malayi 6-phosphofructokinase 0.0106 0.4643 0.4643
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0559 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.2423 0.1975
Giardia lamblia Kinase, PLK 0.0091 0.3868 0.3505
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.4643 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1619 0.1619
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0208 1 1
Trypanosoma brucei polo-like protein kinase 0.0091 0.3868 0.8118
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.3887 0.7976
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0559 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0559 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 1 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.4643 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0559 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0805 0.0298
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.3868 0.3529
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.3887 0.7976
Brugia malayi hypothetical protein 0.0028 0.0523 0.0523
Loa Loa (eye worm) phosphofructokinase 0.0106 0.4643 0.4347
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.4643 0.4326
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.2423 0.4612
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.4643 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326
Loa Loa (eye worm) hypothetical protein 0.0032 0.0742 0.0231
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.4054 0.8423
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0559 1
Leishmania major hypothetical protein, conserved 0.0064 0.2423 0.4612
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0559 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1619 0.1156
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.5206 0.4941
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0559 1
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0559 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1619 0.1619
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.4643 0.4347
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.4643 0.4326
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Brugia malayi phosphofructokinase 0.0106 0.4643 0.4643
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.3868 0.3505
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.2423 0.4612
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0559 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0144 0.6624 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3868 0.3505
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.2359 0.3882
Brugia malayi 6-phosphofructokinase 0.0106 0.4643 0.4643
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.2359 0.3882
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.4054 0.8423
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.2423 0.1975
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.4643 0.4326

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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