Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0025 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.037 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.037 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.037 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.037 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.037 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.037 | 1 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0025 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.037 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0025 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.037 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.