Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | lipase domain protein, putative | 0.1317 | 0.3339 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1317 | 0.3339 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1317 | 0.3339 | 0.5 |
Brugia malayi | Lipase family protein | 0.1317 | 0.3339 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.1317 | 0.3339 | 0.5 |
Loa Loa (eye worm) | lipase | 0.1317 | 0.3339 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1317 | 0.3339 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1317 | 0.3339 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1317 | 0.3339 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.3805 | 0.9918 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1317 | 0.3339 | 0.5 |
Onchocerca volvulus | 0.1317 | 0.3339 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1317 | 0.3339 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 116 | Antineoplastic activity was determined in BDF1 mice invivo implanted with P388 leukemia and t/c was determined at 40 mg/kg ip dose (Q4dx9 treatment) | ChEMBL. | 3625713 |
T/C (functional) | = 120 | In vivo antineoplastic activity was determined in BDF1 mice implanted with P388 leukemia and activity is expressed as T/C at 160 mg/kg ip dose (Q4dx9 treatment) | ChEMBL. | 3625713 |
T/C (functional) | = 124 | In vivo antineoplastic activity was determined in BDF1 mice implanted with P388 leukemia and activity is expressed as T/C at 80 mg/kg ip dose (Q4dx9 treatment) | ChEMBL. | 3625713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.