Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2484 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0284 | 0.0284 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0835 | 0.2995 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0197 | 0.0284 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0835 | 0.2995 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0835 | 0.2995 | 0.2995 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0197 | 0.0284 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0197 | 0.0284 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0197 | 0.0284 | 0.0284 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0197 | 0.0284 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2484 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0638 | 0.2159 | 0.2159 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0835 | 0.2995 | 0.2791 |
Brugia malayi | hypothetical protein | 0.0638 | 0.2159 | 0.2159 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0197 | 0.0284 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0197 | 0.0284 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.0284 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0197 | 0.0284 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0197 | 0.0284 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0197 | 0.0284 | 0.0284 |
Plasmodium falciparum | peptidase, putative | 0.0197 | 0.0284 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0835 | 0.2995 | 0.2791 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0197 | 0.0284 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0835 | 0.2995 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0197 | 0.0284 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0197 | 0.0284 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0197 | 0.0284 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0835 | 0.2995 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2484 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0197 | 0.0284 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2484 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0197 | 0.0284 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0835 | 0.2995 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0284 | 0.0284 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0835 | 0.2995 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0284 | 0.0284 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0197 | 0.0284 | 0.0284 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0197 | 0.0284 | 0.0284 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0835 | 0.2995 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2484 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0197 | 0.0284 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = -7 % | Tested for effect on the production of Lipoxygenase(LO) metabolite, 5,12-diHETE in guinea pig peritoneal polymorphonuclear neutrophils at 30 uM concentration | ChEMBL. | 3114493 |
Reduction (functional) | = 2 % | Tested for effect on the production of Lipoxygenase(LO) metabolite, 5-HETE in guinea pig peritoneal polymorphonuclear neutrophils at 30 uM concentration | ChEMBL. | 3114493 |
Reduction (functional) | = 17 % | Ability to improve the adjuvant induced arthritis in right secondary lesion in rats at oral doses, 33 mg/kg | ChEMBL. | 3114493 |
Reduction (functional) | = 18 % | Antiinflammatory activity was assessed by the ability to improve the adjuvant induced arthritis in right primary lesion in rats at oral doses, 33 mg/kg (volume change in the injected paw measured from day 0 to day 8) | ChEMBL. | 3114493 |
Reduction (functional) | = 23 % | Antiinflammatory activity was assessed improvement of adjuvant induced arthritis in rats, determined by joint mobility of the paw | ChEMBL. | 3114493 |
Reduction (functional) | = 41 % | Antiinflammatory activity was assessed by the ability to improve the adjuvant induced arthritis in left secondary lesion in rats at oral doses, 33 mg/kg (volume change in the injected paw measured from day 9 to day 18) | ChEMBL. | 3114493 |
Reduction (functional) | = 48 % | Tested for effect on the production of cyclooxygenase(COX) metabolite, PGF2-alpha (prostaglandin F2-alpha) of arachidonic acid in guinea pig peritoneal polymorphonuclear neutrophils at 30 uM concentration | ChEMBL. | 3114493 |
Reduction (functional) | = 62 % | Tested for effect on the production of cyclooxygenase(COX) metabolite, PGE-2 (prostaglandin E2) of arachidonic acid in guinea pig peritoneal polymorphonuclear neutrophils at 30 uM concentration | ChEMBL. | 3114493 |
Reduction (functional) | = 90 % | Tested for effect on the production of cyclooxygenase(COX) metabolite, TXB2 of arachidonic acid in guinea pig peritoneal polymorphonuclear neutrophils at 30 uM concentration | ChEMBL. | 3114493 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.