Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.4775 | 0.4775 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.4775 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.4775 | 0.4775 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.2319 | 0.2319 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.