Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0176 | 0.4824 | 0.4824 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0336 | 1 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0863 | 0.0863 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0383 | 0.0195 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0383 | 0.0383 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.4824 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.4824 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0336 | 1 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0336 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.4029 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0.0383 | 0.0383 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0.0383 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0336 | 1 | 1 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0336 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0863 | 0.0863 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 0.4824 | 1 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0336 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0383 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.4029 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0143 | 0.376 | 0.376 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 0.4824 | 0.4824 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0863 | 0.0863 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0383 | 0.0383 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0383 | 1 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0336 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0143 | 0.376 | 0.376 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0311 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0311 | 0.0311 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0863 | 0.0863 |
Onchocerca volvulus | 0.0102 | 0.2418 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.