Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 25B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cdc25c, putative | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0068 | 0 | 0.5 |
Onchocerca volvulus | 0.0068 | 0 | 0.5 | |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0171 | 1 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0076 | 0.0755 | 0.0755 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0068 | 0 | 0.5 |
Onchocerca volvulus | 0.0068 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0755 | 0.0755 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0171 | 1 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 1 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0068 | 0 | 0.5 |
Onchocerca volvulus | 0.0068 | 0 | 0.5 | |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 1 | 0.5 |
Onchocerca volvulus | 0.0068 | 0 | 0.5 | |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 1 | 0.5 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0171 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0171 | 1 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0068 | 0 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0171 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.4 uM | Inhibitory concentration to human cell division cycle 25B (Cdc25B) | ChEMBL. | 15026048 |
IC50 (binding) | = 3.4 uM | Inhibitory concentration to human cell division cycle 25B (Cdc25B) | ChEMBL. | 15026048 |
Selectivity (binding) | = 25 uM | Selectivity against protein phosphatase 2A | ChEMBL. | 15026048 |
Selectivity (binding) | = 25 uM | Selectivity against protein phosphatase 2A | ChEMBL. | 15026048 |
Selectivity (binding) | > 30 uM | Selectivity against protein tyrosine phosphatase 1B | ChEMBL. | 15026048 |
Selectivity (binding) | > 30 uM | Selectivity against protein tyrosine phosphatase alpha | ChEMBL. | 15026048 |
Selectivity (binding) | > 30 uM | Selectivity against protein tyrosine phosphatase 1B | ChEMBL. | 15026048 |
Selectivity (binding) | > 30 uM | Selectivity against protein tyrosine phosphatase alpha | ChEMBL. | 15026048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.