Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.3823 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.3823 | 1 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.3358 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.3358 | 0 | 0.5 |
Onchocerca volvulus | 0.3823 | 1 | 0.5 | |
Brugia malayi | acyl-CoA desaturase | 0.3358 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.3358 | 0 | 0.5 |
Onchocerca volvulus | 0.3823 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.3823 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.00000022 M | Cytotoxicity against P388 leukemia | ChEMBL. | 8389875 |
IC50 (binding) | 0 uM | Inhibition of DNA topoisomerase II from Rat Liver measured as 50% reduction in the amount of minicircle DNA relative to the control; Not tested | ChEMBL. | 8389875 |
IC50 (binding) | > 100 uM | Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the control | ChEMBL. | 8389875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.