Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2498 | 0.2498 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.2849 | 0.0469 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.2849 | 0.0469 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2498 | 0.2415 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0108 | 0.0381 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.2849 | 0.2849 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0108 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0108 | 0.0000000023304 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.2849 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2498 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.2849 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0021 | 0.2849 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2498 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2498 | 0.2498 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 0.0469 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.2849 | 0.2771 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2498 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.2849 | 0.0469 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.2849 | 0.0469 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.2849 | 0.0469 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0108 | 0.0434 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2498 | 0.8765 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.2849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2849 | 0.2771 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.2849 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2498 | 0.8765 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.2849 | 0.0469 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2498 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.2849 | 0.2771 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 0.0469 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.2849 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.2849 | 0.0469 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2498 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.2849 | 0.2849 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.2849 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2498 | 0.8716 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2498 | 0.8716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.