Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2498 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.2849 | 0.2771 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2498 | 0.2498 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.2849 | 0.0469 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0021 | 0.2849 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0108 | 0.0381 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2498 | 0.2498 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2498 | 0.8716 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.2849 | 0.0469 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2498 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.2849 | 0.0469 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2498 | 0.8765 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2849 | 0.2771 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2498 | 0.5 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.2849 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2498 | 0.8765 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.2849 | 0.2849 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.2849 | 0.0469 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2498 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.2849 | 0.2849 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.2849 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.2849 | 0.2771 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0108 | 0.0000000023304 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 0.0469 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.2849 | 0.0469 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0108 | 0.0108 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.2849 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 1 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.2849 | 0.0469 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0108 | 0.0381 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2498 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0108 | 0.0434 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.2849 | 0.0469 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.2849 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2498 | 0.2415 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.2849 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2498 | 0.8716 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.2849 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.