Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2498 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2498 | 0.8716 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.2849 | 0.2771 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.2849 | 0.2771 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.2849 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 0.0469 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0021 | 0.2849 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0108 | 0.0381 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.2849 | 0.0469 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 0.0469 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.2849 | 0.0469 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.2849 | 0.2849 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.2849 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0108 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0108 | 0.0000000023304 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.2849 | 0.0469 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.2849 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.2849 | 0.0469 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.2849 | 0.0469 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.2849 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0108 | 0.0108 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0108 | 0.0434 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2498 | 0.8716 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2849 | 0.2771 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2498 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2498 | 0.8765 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.2849 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.2849 | 0.0469 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2498 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.2849 | 0.2849 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.2849 | 0.0469 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2498 | 0.2498 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.2849 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.2849 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2498 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2498 | 0.2498 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2498 | 0.8765 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2498 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.2849 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2498 | 0.2415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.