Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | serpin precursor | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 402 aa | 383 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | gastrulation defective protein 1 | 0.0569 | 0.9953 | 0.9953 |
Echinococcus granulosus | cyclin dependent kinase 19 | 0.0571 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0345 | 0.472 | 0.4434 |
Echinococcus multilocularis | cyclin dependent kinase 19 | 0.0571 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0345 | 0.472 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0345 | 0.472 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0325 | 0.4241 | 0.8869 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0345 | 0.472 | 0.472 |
Echinococcus multilocularis | zinc finger protein | 0.0222 | 0.1831 | 0.1387 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0325 | 0.4241 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0345 | 0.472 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0345 | 0.472 | 1 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0242 | 0.232 | 0.1903 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0345 | 0.472 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0345 | 0.472 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0345 | 0.472 | 0.4434 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0571 | 1 | 1 |
Brugia malayi | MBOAT family protein | 0.0242 | 0.232 | 0.232 |
Loa Loa (eye worm) | CMGC/CDK/CDK8 protein kinase | 0.0571 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0345 | 0.472 | 0.4434 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0345 | 0.472 | 0.472 |
Schistosoma mansoni | zinc finger protein | 0.0242 | 0.232 | 0.1903 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0181 | 0.0884 | 0.0954 |
Loa Loa (eye worm) | MBOAT family protein | 0.0242 | 0.232 | 0.232 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0345 | 0.472 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0143 | 0 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0222 | 0.1831 | 0.1387 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0345 | 0.472 | 1 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0242 | 0.232 | 0.1903 |
Trypanosoma brucei | GMP reductase | 0.0345 | 0.472 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0345 | 0.472 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0345 | 0.472 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0325 | 0.4241 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0345 | 0.472 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0345 | 0.472 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0345 | 0.472 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.47 uM | Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex formation in t-PA-induced fibrin clot lysis assay | ChEMBL. | 12729646 |
IC50 (binding) | = 0.47 uM | Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex formation in t-PA-induced fibrin clot lysis assay | ChEMBL. | 12729646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.