Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cyclin C | 0.0083 | 0.2434 | 0.2434 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0047 | 0.0962 | 0.0962 |
Schistosoma mansoni | kinase | 0.0049 | 0.106 | 0.4357 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0058 | 0.1414 | 0.5809 |
Echinococcus granulosus | cyclin dependent kinase | 0.0047 | 0.0962 | 0.3954 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0049 | 0.106 | 0.4357 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0047 | 0.0962 | 0.0962 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0928 | 0.0928 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0047 | 0.0962 | 1 |
Echinococcus multilocularis | cyclin | 0.0083 | 0.2434 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0047 | 0.0962 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0265 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0047 | 0.0962 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0047 | 0.0962 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0962 | 0.3954 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0047 | 0.0962 | 0.3954 |
Echinococcus granulosus | cyclin | 0.0083 | 0.2434 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0047 | 0.0962 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0047 | 0.0962 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0047 | 0.0962 | 0.3954 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0058 | 0.1414 | 0.5809 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0047 | 0.0962 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0047 | 0.0962 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0047 | 0.0962 | 0.0962 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0047 | 0.0962 | 0.3954 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0047 | 0.0962 | 1 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.0083 | 0.2434 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0047 | 0.0962 | 0.5183 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.106 | 0.4357 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0047 | 0.0962 | 0.3954 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0083 | 0.2434 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0047 | 0.0962 | 0.3954 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0047 | 0.0962 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0049 | 0.106 | 0.4357 |
Trichomonas vaginalis | cyclin H, putative | 0.0069 | 0.1857 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.1857 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0151 | 0.528 | 0.528 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0151 | 0.528 | 0.528 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.0962 | 0.5183 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0047 | 0.0962 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.0962 | 0.5183 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0083 | 0.2434 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0056 | 0.1316 | 0.7086 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0047 | 0.0962 | 1 |
Loa Loa (eye worm) | cyclin C | 0.0083 | 0.2434 | 0.2434 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0047 | 0.0962 | 0.3954 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0047 | 0.0962 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0047 | 0.0962 | 0.0962 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0962 | 0.3954 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0047 | 0.0962 | 0.3954 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0049 | 0.106 | 0.5711 |
Brugia malayi | cyclin-dependent kinase 9 | 0.0049 | 0.106 | 0.106 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0049 | 0.106 | 0.106 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.0962 | 0.5183 |
Brugia malayi | cell division control protein 2 homolog | 0.0047 | 0.0962 | 0.0962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.