Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0182 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0182 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.007 | 0.2554 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.007 | 0.2554 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0031 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0182 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0031 | 0 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0182 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.007 | 0.2554 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.007 | 0.2554 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0182 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.007 | 0.2554 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0182 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0182 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.007 | 0.2554 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0182 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.