Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.1205 | 0.1262 |
Brugia malayi | hypothetical protein | 0.0304 | 0.0451 | 0.0451 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0623 | 0.2138 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.2027 | 0.9553 | 1 |
Echinococcus multilocularis | presenilin | 0.0623 | 0.2138 | 0.1853 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0623 | 0.2138 | 0.5 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.2027 | 0.9553 | 0.9553 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0585 | 0.1935 | 0.1631 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0623 | 0.2138 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.079 | 0.3019 | 1 |
Brugia malayi | Presenilin family protein | 0.0623 | 0.2138 | 0.2138 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0585 | 0.1935 | 0.1935 |
Trypanosoma brucei | Aph-1 protein, putative | 0.079 | 0.3019 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.079 | 0.3019 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0623 | 0.2138 | 0.1853 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.077 | 0.2914 | 0.2706 |
Toxoplasma gondii | hypothetical protein | 0.0218 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.0451 | 0.0472 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.2027 | 0.9553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.7636 | 0.7993 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0623 | 0.2138 | 0.5 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0585 | 0.1935 | 0.1631 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.2027 | 0.9553 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0623 | 0.2138 | 1 |
Brugia malayi | hypothetical protein | 0.0304 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0894 | 0.3569 | 0.3736 |
Echinococcus granulosus | presenilin | 0.0623 | 0.2138 | 0.1853 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0585 | 0.1935 | 0.2026 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.2027 | 0.9553 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.36 ug ml-1 | Concentration required to inhibit the growth of L1210 leukemia cells | ChEMBL. | 2754697 |
ED50 (functional) | = 2.36 ug ml-1 | Concentration required to inhibit the growth of L1210 leukemia cells | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound 80 at mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 40 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 20 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 10 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 5 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
T/C (functional) | = 125 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 125 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 132 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 132 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 135 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 135 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 147 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 147 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 153 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 80 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 153 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 80 mg/kg | ChEMBL. | 2754697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.