Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | putative neuropeptide receptor | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Giardia lamblia | Hypothetical protein | 0.0079 | 0.0396 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | Serotonin receptor | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | G protein-coupled receptor | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0134 | 1 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | AKH receptor | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | follicle stimulating hormone receptor | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Giardia lamblia | Hypothetical protein | 0.0079 | 0.0396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0097 | 0.3487 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0079 | 0.0396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0134 | 1 | 1 |
Brugia malayi | ORL1-like opioid receptor | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | RE15519p | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0097 | 0.3487 | 0.3487 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0079 | 0.0396 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.0396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.9604 | 0.9604 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | G-protein coupled receptor | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Onchocerca volvulus | 0.0134 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | neuropeptide F receptor | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | Dopamine receptor protein 2 | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | GnHR receptor homolog | 0.0097 | 0.3487 | 0.5 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0134 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0134 | 1 | 1 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | Melatonin receptor type 1A | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0097 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0097 | 0.3487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3487 | 0.3487 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 46 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
IC50 (functional) | = 46 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.