Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.023 | 0.0215 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0089 | 0.2062 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0234 | 0.5665 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1077 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0667 | 0.0747 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.023 | 0.0215 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.023 | 0.0215 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0089 | 0.2062 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0667 | 0.6149 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.023 | 0.0215 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0593 | 0.0578 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0667 | 0.0747 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0667 | 0.6149 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.023 | 0.0215 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0667 | 0.0653 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0089 | 0.2062 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0667 | 0.6149 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1077 | 1 |
Chlamydia trachomatis | peptide deformylase | 0.0234 | 0.5665 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0089 | 0.2062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0685 | 0.6317 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0667 | 0.6149 |
Treponema pallidum | polypeptide deformylase (def) | 0.0234 | 0.5665 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0234 | 0.5665 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.023 | 0.0215 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0234 | 0.5665 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0593 | 0.0578 |
Schistosoma mansoni | hypothetical protein | 0.0408 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0341 | 0.832 | 0.8317 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.0416 | 0.3792 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.832 | 0.8317 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0667 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0056 | 0.0407 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.119 | 0.1715 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0667 | 0.0653 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.023 | 0.0215 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0264 | 0.0249 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0552 | 0.5065 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0685 | 0.067 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0059 | 0.0044 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0416 | 0.3792 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0667 | 0.0653 |
Echinococcus multilocularis | geminin | 0.0341 | 0.832 | 0.8317 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0667 | 0.0653 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0059 | 0.0044 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.023 | 0.2042 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0593 | 0.0578 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.023 | 0.2042 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0667 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0685 | 0.6317 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.023 | 0.0215 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0667 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0492 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.023 | 0.2042 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0059 | 0.0434 |
Toxoplasma gondii | hypothetical protein | 0.0234 | 0.5665 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0234 | 0.5665 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1077 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0264 | 0.0249 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0667 | 0.0653 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.023 | 0.2042 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.0416 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.0264 | 0.0249 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0552 | 0.5065 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0667 | 0.6149 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0264 | 0.0249 |
Plasmodium falciparum | peptide deformylase | 0.0234 | 0.5665 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.023 | 0.0215 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.832 | 0.8317 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0667 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0264 | 0.0249 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0593 | 0.0578 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.001 | 0.0089 | 0.0716 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0089 | 0.2062 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.023 | 0.0215 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1077 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0089 | 0.2062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0667 | 0.6149 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0552 | 0.0537 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0408 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0667 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0264 | 0.0249 |
Mycobacterium ulcerans | peptide deformylase | 0.0234 | 0.5665 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0667 | 0.0747 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.1352 | 0.1338 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0667 | 0.0653 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0089 | 0.2062 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0264 | 0.0249 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.