Detailed information for compound 690738

Basic information

Technical information
  • TDR Targets ID: 690738
  • Name: N-[3-(1,1-dioxo-1,2-thiazolidin-2-yl)phenyl]- 2,2-dimethylpropanamide
  • MW: 296.385 | Formula: C14H20N2O3S
  • H donors: 1 H acceptors: 3 LogP: 1.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)(C)C)Nc1cccc(c1)N1CCCS1(=O)=O
  • InChi: 1S/C14H20N2O3S/c1-14(2,3)13(17)15-11-6-4-7-12(10-11)16-8-5-9-20(16,18)19/h4,6-7,10H,5,8-9H2,1-3H3,(H,15,17)
  • InChiKey: ISSNSJWZNRPXRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(1,1-dioxo-1,2-thiazolidin-2-yl)phenyl]-2,2-dimethyl-propanamide
  • N-[3-(1,1-diketo-1,2-thiazolidin-2-yl)phenyl]-2,2-dimethyl-propionamide
  • ZINC05339196

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0667 0.6149
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1077 1
Treponema pallidum polypeptide deformylase (def) 0.0234 0.5665 0.5
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0537
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0089 0.2062 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0667 0.6149
Mycobacterium ulcerans peptide deformylase 0.0234 0.5665 1
Schistosoma mansoni pyruvate kinase 0.0033 0.0667 0.0653
Toxoplasma gondii hypothetical protein 0.0234 0.5665 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0492 0.0478
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1077 1
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Trypanosoma brucei Peptide deformylase 2 0.0089 0.2062 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Schistosoma mansoni pyruvate kinase 0.0033 0.0667 0.0653
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0685 0.6317
Echinococcus multilocularis GPCR, family 2 0.0016 0.023 0.0215
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1352 0.1338
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1077 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0685 0.6317
Plasmodium falciparum pyruvate kinase 0.0033 0.0667 0.0747
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0667 0.0747
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0416 0.3792
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0667 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0089 0.2062 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Echinococcus multilocularis dnaJ subfamily B 0.0408 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.023 0.2042
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0667 0.6149
Loa Loa (eye worm) hypothetical protein 0.0023 0.0416 0.3792
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0667 1
Leishmania major polypeptide deformylase-like protein, putative 0.0089 0.2062 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0667 0.6149
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.023 0.2042
Chlamydia trachomatis peptide deformylase 0.0234 0.5665 1
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0667 0.0747
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0234 0.5665 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0056 0.0407
Echinococcus granulosus pyruvate kinase 0.0033 0.0667 0.0653
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Schistosoma mansoni hypothetical protein 0.0341 0.832 0.8317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.119 0.1715
Echinococcus granulosus geminin 0.0341 0.832 0.8317
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0234 0.5665 1
Giardia lamblia Pyruvate kinase 0.0033 0.0667 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0667 1
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0416 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.023 0.2042
Echinococcus granulosus GPCR family 2 0.0016 0.023 0.0215
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.5065
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Schistosoma mansoni hypothetical protein 0.0408 1 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Schistosoma mansoni pyruvate kinase 0.0017 0.0264 0.0249
Trypanosoma brucei Polypeptide deformylase 1 0.0089 0.2062 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0667 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.5065
Loa Loa (eye worm) hypothetical protein 0.005 0.1077 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0667 0.0653
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0578
Echinococcus multilocularis geminin 0.0341 0.832 0.8317
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0234 0.5665 0.5
Schistosoma mansoni hypothetical protein 0.0341 0.832 0.8317
Trypanosoma cruzi Peptide deformylase 2, putative 0.0089 0.2062 1
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0578
Plasmodium falciparum peptide deformylase 0.0234 0.5665 1
Schistosoma mansoni hypothetical protein 0.0034 0.0685 0.067
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0089 0.0716
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0434
Brugia malayi Latrophilin receptor protein 2 0.0016 0.023 0.2042
Plasmodium vivax peptide deformylase, putative 0.0234 0.5665 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0667 0.6149
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Trypanosoma cruzi Peptide deformylase 2, putative 0.0089 0.2062 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0667 0.6149
Echinococcus multilocularis pyruvate kinase 0.0033 0.0667 0.0653
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0667 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0667 0.0653

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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