Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0125 | 0.4639 | 0.7217 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 0.6428 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0304 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.6428 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0161 | 0.6428 | 0.7465 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0304 | 0.0571 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0304 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0304 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0135 | 0.5127 | 0.7977 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0304 | 0.5 |
Onchocerca volvulus | 0.0093 | 0.311 | 0.311 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0304 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.5332 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.5332 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.4639 | 0.8701 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0304 | 0.0474 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0125 | 0.4639 | 0.7217 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0304 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 0.6428 | 0.7465 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.6428 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.8611 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 0.5127 | 0.9616 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0304 | 0.0353 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 0.5127 | 0.9616 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0304 | 0.0474 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0304 | 0.0353 |
Trichomonas vaginalis | set domain proteins, putative | 0.0235 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.8611 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0304 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.